Rabbit Polyclonal CBX7 Antibody

The CBX7 antibody is a crucial tool in studying the Polycomb group (PcG) proteins, which regulate epigenetic gene silencing and chromatin organization. CBX7 (Chromobox Homolog 7) is a core component of the Polycomb Repressive Complex 1 (PRC1), functioning in transcriptional repression through chromatin modification, including histone H2A ubiquitination. It plays roles in cell differentiation, senescence, and cancer progression, with context-dependent oncogenic or tumor-suppressive activities reported in various cancers (e.g., overexpressed in prostate cancer but downregulated in lung and thyroid cancers). Researchers use CBX7 antibodies to investigate its expression patterns, subcellular localization, and interactions in developmental biology, stem cell regulation, and disease mechanisms. These antibodies are typically developed against specific epitopes, such as the N-terminal chromodomain or C-terminal regions, and validated for applications like Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Challenges include ensuring specificity due to homology within the CBX protein family (CBX1-8). Recent studies highlight CBX7's therapeutic potential, driving demand for reliable antibodies to explore its dual roles in cancer and its emerging connections to metabolic regulation and immune response. Commercial CBX7 antibodies are available from multiple suppliers, with validation data critical for interpreting experimental results in epigenetic research.