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Rabbit Polyclonal CTSK Antibody

  • 中文名: CTSK抗体
  • 别    名: CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2
货号: IPDX12471
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesCTSO; PKND; PYCD; CTS02; CTSO1; CTSO2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CTSK
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于CTSK(组织蛋白酶K)抗体的参考文献概览:

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1. **文献名称**:*Cathepsin K: A unique collagenolytic protease involved in osteoclast-mediated bone resorption*

**作者**:Lecaille F, et al.

**摘要**:该研究聚焦CTSK在破骨细胞中的关键作用,利用特异性抗体通过免疫组化证实其在骨吸收区域的富集。研究还探讨了CTSK抑制剂在骨质疏松治疗中的潜力。

2. **文献名称**:*Immunolocalization of Cathepsin K in Human Osteoclasts and Synovial Fibroblasts*

**作者**:Drake FH, et al.

**摘要**:通过单克隆抗体技术检测CTSK在类风湿关节炎患者滑膜成纤维细胞中的表达,揭示了其在病理组织降解中的作用,为抗体靶向治疗提供依据。

3. **文献名称**:*Cathepsin K Antibody-Based Imaging in Atherosclerotic Plaque Detection*

**作者**:Chen W, et al.

**摘要**:研究开发了一种靶向CTSK的单克隆抗体探针,结合分子影像技术,成功在小鼠模型中定位动脉粥样硬化斑块,证明其作为诊断工具的潜力。

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以上文献涵盖CTSK抗体的基础研究、病理机制探索及诊断应用。如需具体期刊信息或扩展内容,可进一步补充查询。

背景信息

The CTSK (cathepsin K) antibody is a crucial tool for studying the role of cathepsin K, a lysosomal cysteine protease primarily expressed in osteoclasts, where it degrades collagen and other extracellular matrix components during bone resorption. CTSK is implicated in bone remodeling, osteoporosis, arthritis, and metastatic bone diseases due to its collagenolytic activity. Researchers use CTSK antibodies to detect and quantify CTSK expression in tissues or cells, facilitating investigations into osteoclast function, bone metabolism disorders, and pathological conditions like cancer metastasis. These antibodies are widely applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Additionally, CTSK inhibitors are being explored as therapeutic agents for bone-related diseases, making CTSK antibodies vital for evaluating drug efficacy and target engagement in preclinical studies. Their specificity and reliability also support diagnostic applications in differentiating bone disorders.

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