| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MRP; ABCC; GS-X; MRP1; ABC29 |
| WB Predicted band size | 172 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCC1抗体的3篇示例参考文献(基于学术文献的常见研究方向，内容为示例性概括)：
1. **文献名称**：*Characterization of monoclonal antibodies against human ABCC1 (MRP1) and their application in detecting MRP overexpression in cancer cells*
**作者**：Deeley, R.G., et al.
**摘要**：研究报道了针对ABCC1蛋白不同表位的单克隆抗体的开发与验证，通过免疫印迹和免疫组化证实其在多种耐药性癌细胞系中的高表达，为ABCC1在肿瘤多药耐药性中的作用提供实验依据。
2. **文献名称**：*Comparative analysis of ABCC1 antibody specificity in human tissues using immunohistochemistry*
**作者**：Létourneau, I.J., et al.
**摘要**：比较了不同商业来源的ABCC1抗体在正常及病理组织中的特异性，发现某些抗体存在交叉反应性，提出标准化验证流程以提高实验可靠性，尤其在肝脏和肾脏组织中的应用需谨慎。
3. **文献名称**：*ABCC1-mediated efflux in neurological disorders: Antibody-based localization in brain endothelial cells*
**作者**：Hartz, A.M.S., et al.
**摘要**：利用ABCC1特异性抗体进行免疫荧光染色，揭示其在血脑屏障内皮细胞中的极性分布，提示其在限制神经毒素积累中的作用，为阿尔茨海默病等疾病的治疗靶点研究提供依据。
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注：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science检索最新研究，并核对作者及摘要准确性。
ABCC1 (ATP-binding cassette subfamily C member 1), also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane transporter belonging to the ABC protein superfamily. It plays a critical role in cellular detoxification by effluxing a wide range of endogenous and exogenous compounds, including glutathione-conjugated metabolites, anticancer drugs (e.g., vinca alkaloids, anthracyclines), and organic anions. ABCC1 is expressed in various tissues, such as the liver, kidneys, lungs, and blood-brain barrier, and its overexpression is linked to multidrug resistance in cancer chemotherapy.
ABCC1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ABCC1 levels in cancer cells, normal tissues, or experimental models. Specific monoclonal or polyclonal antibodies target distinct epitopes (e.g., cytoplasmic domains or extracellular loops) to ensure detection specificity. Validated antibodies help investigate ABCC1's role in drug resistance mechanisms, cellular stress responses, and disease progression. Additionally, they aid in evaluating ABCC1 as a potential biomarker or therapeutic target. Researchers must verify antibody specificity using knockout controls or blocking peptides to avoid cross-reactivity with homologous ABC transporters like ABCC2 or ABCC3.
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