| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human BRMS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BRMS1抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*BRMS1 suppresses breast cancer metastasis by modulating epigenetic silencing of multiple target genes*
**作者**：Samant RS et al.
**摘要**：本研究通过Western blot和免疫组化(使用BRMS1特异性抗体)分析了乳腺癌细胞系及组织样本中BRMS1蛋白的表达，发现其通过组蛋白修饰复合体调控下游基因的表观遗传沉默，从而抑制肿瘤转移。
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2. **文献名称**：*BRMS1 expression correlates with prognosis in non-small cell lung cancer*
**作者**：Liu Y et al.
**摘要**：利用BRMS1抗体对肺癌组织进行免疫组化染色，发现BRMS1低表达与患者淋巴结转移和不良预后显著相关，提示其作为肺癌转移预测生物标志物的潜力。
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3. **文献名称**：*BRMS1 interacts with the NuRD complex to regulate EMT in ovarian cancer*
**作者**：Zhang H et al.
**摘要**：通过免疫共沉淀(使用BRMS1抗体)和蛋白质组学分析，揭示了BRMS1与NuRD复合物相互作用，抑制卵巢癌细胞的上皮-间质转化(EMT)，为靶向转移机制提供新方向。
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如需具体文献，建议通过PubMed或Web of Science以“BRMS1 antibody”为关键词检索，并筛选涉及实验应用的论文。
The BRMS1 (Breast Cancer Metastasis Suppressor 1) antibody is a research tool used to detect the BRMS1 protein, a key player in regulating cancer metastasis. BRMS1. first identified as a metastasis suppressor in breast cancer, is part of the mSin3-histone deacetylase (HDAC) complex, which modulates gene expression by altering chromatin structure. It suppresses metastasis by downregulating pro-metastatic genes (e.g., osteopontin, uPAR) while upregulating metastasis-inhibiting pathways, impacting cell-cell communication, invasion, and angiogenesis. BRMS1 is implicated in multiple cancers, including breast, lung, and melanoma, where its reduced expression correlates with metastatic potential and poor prognosis.
The BRMS1 antibody enables researchers to study protein localization, expression levels, and interactions in cellular and tissue samples via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring BRMS1’s role in metastasis suppression, therapeutic resistance, and molecular mechanisms involving HDAC activity or NF-κB signaling. Studies using this antibody have highlighted BRMS1’s dual role in transcriptional regulation and its potential as a prognostic biomarker or therapeutic target. However, variability in antibody specificity across isoforms and tissues requires careful validation. Ongoing research aims to clarify BRMS1’s context-dependent functions and its utility in personalized cancer therapies.
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