| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AQP9; AQP7L; AQPap; GLYCQTL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human AQP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AQP7抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase"*
**作者**：Kishida, K., et al.
**摘要**：该研究通过AQP7抗体检测脂肪组织中AQP7蛋白的表达，发现AQP7缺失会导致甘油代谢异常，促进脂肪堆积和肥胖发生，揭示了AQP7在脂肪细胞功能中的关键作用。
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2. **文献名称**：*"Aquaporin 7 is involved in the regulation of adipocyte differentiation and lipid accumulation"*
**作者**：Hibuse, T., et al.
**摘要**：利用AQP7特异性抗体进行Western blot和免疫组化分析，研究发现AQP7通过调节脂肪细胞分化过程中的甘油转运，影响脂联素表达和脂质代谢，提示其与代谢综合征的潜在关联。
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3. **文献名称**：*"Role of aquaporin 7 in the pathogenesis of type 2 diabetes mellitus"*
**作者**：Kuriyama, H., et al.
**摘要**：通过AQP7抗体在糖尿病模型中的研究，发现AQP7在胰岛素抵抗状态下表达下调，导致脂肪细胞甘油释放减少，可能加剧高血糖和脂质异常，为糖尿病治疗提供了新靶点。
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4. **文献名称**：*"Aquaporins in health and disease: An overview focusing on the gut and exocrine glands"*
**作者**：Laforenza, U., et al.
**摘要**：综述类文献，总结了AQP7的结构与功能，并强调其在脂肪代谢中的重要性。文中提到多种AQP7抗体的应用，包括定位研究和疾病模型中蛋白表达的定量分析。
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以上文献均涉及AQP7抗体的实验应用(如蛋白定位、表达量检测)，并探讨了AQP7在代谢疾病中的机制。如需具体期刊或年份等细节，可进一步补充。
Aquaporin-7 (AQP7) is a member of the aquaporin family of transmembrane water channel proteins, primarily involved in the transport of water and small solutes like glycerol. Expressed predominantly in adipose tissue, testis, and the kidney, AQP7 plays a critical role in glycerol efflux from adipocytes, linking lipid metabolism to systemic energy homeostasis. Dysregulation of AQP7 has been implicated in metabolic disorders, including obesity, insulin resistance, and diabetes, making it a research focus in metabolic physiology and pathophysiology.
AQP7 antibodies are essential tools for detecting and quantifying AQP7 protein expression in various experimental models. These antibodies enable researchers to study AQP7's tissue-specific distribution, subcellular localization, and dynamic regulation under physiological or pathological conditions, such as fasting, high-fat diets, or hormonal stimulation. Commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence, AQP7 antibodies help elucidate its role in glycerol metabolism, adipocyte function, and systemic glucose-lipid crosstalk. Recent studies also explore AQP7's potential as a biomarker or therapeutic target in metabolic syndrome. Validation of antibody specificity via knockout controls or peptide blocking is critical due to structural similarities among aquaporin family members.
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