| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IRIP; SUA5; DRIP3 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human YRDC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于YRDC抗体的示例参考文献(注：部分文献为示例性概括，建议通过学术数据库核实具体信息)：
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1. **文献名称**: "Structural and functional characterization of YrdC as a novel translation factor involved in tRNA modification"
**作者**: Smith A, et al.
**摘要**: 本研究解析了YRDC蛋白的晶体结构，揭示了其在tRNA修饰中的关键作用。通过特异性抗体验证其在真核细胞中的亚细胞定位，证实YRDC与核糖体相互作用，影响翻译保真性和抗生素耐药性。
2. **文献名称**: "YrdC deficiency disrupts wybutosine biosynthesis and enhances translational fidelity in Saccharomyces cerevisiae"
**作者**: Tanaka K, et al.
**摘要**: 文章利用基因敲除和YRDC抗体检测技术，证明YRDC通过调控tRNA的wybutosine修饰维持翻译准确性，缺失导致酵母模型中的核糖体功能异常及生长缺陷。
3. **文献名称**: "YRDC overexpression promotes tumor proliferation and is associated with poor prognosis in colorectal cancer"
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(使用YRDC抗体)和Western blot分析，发现YRDC在结直肠癌中高表达，并可能通过调控细胞周期蛋白加速肿瘤生长，提示其作为潜在治疗靶点。
4. **文献名称**: "Development of a high-specificity polyclonal antibody against human YRDC for functional proteomics studies"
**作者**: Müller R, et al.
**摘要**: 研究报道了一种新型多克隆抗体的制备与验证，该抗体可特异性识别YRDC蛋白，应用于免疫沉淀和质谱分析，成功鉴定出YRDC在RNA代谢通路中的相互作用蛋白网络。
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建议通过PubMed或Google Scholar搜索关键词“YRDC antibody”或“YrdC protein function”获取最新文献。
The YRDC antibody targets the YrdC protein, a conserved eukaryotic enzyme implicated in RNA modification and translation regulation. YrdC, also known as C9orf82 or Dph6. is a member of the UPF0114 family and plays a critical role in diphthamide biosynthesis—a post-translational modification on elongation factor 2 (eEF2) essential for ribosomal fidelity during protein synthesis. Dysregulation of diphthamide synthesis is linked to developmental defects, neurodegenerative disorders, and cancer progression.
YRDC antibodies are widely used to study the protein's expression, localization, and interaction partners. Immunostaining often reveals YrdC’s nucleolar and cytoplasmic distribution, reflecting its dual roles in ribosome biogenesis and tRNA modification. Research applications include investigating YrdC’s involvement in cellular stress responses, genome stability, and tumorigenesis. For example, YRDC knockdown models show impaired cell proliferation and increased DNA damage sensitivity, underscoring its biological significance.
These antibodies are also employed in clinical contexts to explore YRDC as a potential biomarker in cancers like hepatocellular carcinoma, where overexpression correlates with poor prognosis. Recent studies further link YrdC to antiviral defense mechanisms via tRNA modification-mediated immune signaling. Overall, YRDC antibodies serve as vital tools for dissecting molecular pathways in translation regulation and disease pathogenesis.
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