| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | APEL; XNPEP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human APLN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于APLN抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：*Apelin Antibody Attenuates Hypertension and Cardiac Hypertrophy in Rodent Models*
**作者**：Smith A, et al.
**摘要**：研究通过注射APLN中和抗体，发现其可降低自发性高血压大鼠的血压，并逆转心肌肥厚，提示APLN信号通路在高血压病理中的作用。
2. **文献名称**：*Targeting APLN with Monoclonal Antibody Inhibits Tumor Angiogenesis in Breast Cancer*
**作者**：Chen L, et al.
**摘要**：该研究开发了针对APLN的单克隆抗体，证明其能特异性阻断APLN与受体结合，抑制乳腺癌小鼠模型中肿瘤血管生成，减缓肿瘤生长。
3. **文献名称**：*APLN Neutralizing Antibody Improves Insulin Sensitivity in Obese Mice*
**作者**：Wang X, et al.
**摘要**：实验表明，APLN抗体处理可改善高脂饮食诱导的肥胖小鼠的胰岛素抵抗，机制可能与调节脂肪组织炎症和脂质代谢相关。
4. **文献名称**：*Development of a High-Affinity APLN Antibody for Cardiovascular Disease Biomarker Detection*
**作者**：Kim J, et al.
**摘要**：报道了一种新型高亲和力APLN抗体的制备方法，成功应用于ELISA检测，为心血管疾病患者血清APLN水平的临床评估提供了新工具。
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**注意**：以上内容为模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
**Background of APLN Antibodies**
APLN (apelin) antibodies are immunological tools targeting apelin, a peptide hormone encoded by the *APLN* gene. Apelin plays critical roles in cardiovascular homeostasis, including vasodilation, angiogenesis, and fluid balance, by binding to its G protein-coupled receptor, APJ (APLNR). APLN antibodies are widely used in research to detect and quantify apelin expression in tissues or biological fluids via techniques like Western blot, immunohistochemistry, or ELISA.
Apelin's involvement in pathological conditions, such as heart failure, hypertension, and metabolic disorders, has driven interest in developing therapeutic antibodies. For instance, neutralizing APLN antibodies may modulate APJ signaling, offering potential in treating cardiovascular diseases or cancer, where apelin promotes tumor angiogenesis. Additionally, APLN antibodies aid in studying apelin's regulatory roles in obesity, diabetes, and inflammation.
Both monoclonal and polyclonal APLN antibodies are available, with specificity validated across species. Challenges remain in ensuring antibody selectivity due to apelin's multiple bioactive isoforms. Recent advances include humanized APLN antibodies for preclinical therapeutic exploration, though clinical applications are still emerging. Overall, APLN antibodies serve as vital reagents for unraveling apelin's physiological and pathological mechanisms, bridging translational research toward targeted therapies.
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