| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SCELL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNF185 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF185抗体的3篇参考文献示例(基于公开文献内容概括，具体文献需根据实际检索结果调整)：
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1. **文献名称**: *ZNF185 as a potential tumor suppressor in prostate cancer: Immunohistochemical analysis of protein expression*
**作者**: Smith J, et al.
**摘要**: 本研究利用ZNF185抗体对前列腺癌组织进行免疫组化分析，发现ZNF185在癌组织中的表达显著低于正常组织，且低表达与患者预后不良相关。结果提示ZNF185可能通过调控细胞黏附通路抑制肿瘤进展。
2. **文献名称**: *Role of ZNF185 in hepatocellular carcinoma: Correlation with clinical outcomes*
**作者**: Li X, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用ZNF185特异性抗体)，作者发现肝细胞癌中ZNF185表达下调与肿瘤侵袭性增强和患者生存率降低相关。机制研究表明ZNF185可能通过调节细胞骨架重组抑制转移。
3. **文献名称**: *ZNF185 regulates cell migration via integrin signaling in lung cancer cell lines*
**作者**: Wang Y, et al.
**摘要**: 本研究使用ZNF185抗体进行蛋白质表达检测，发现ZNF185在肺癌细胞中高表达可抑制迁移能力。通过siRNA敲降实验，证实其通过整合素-细胞外基质相互作用调控肿瘤细胞运动性。
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**注意**：以上文献为示例，实际引用需通过PubMed、Google Scholar等平台检索真实文献(关键词：ZNF185 antibody, immunohistochemistry, cancer等)。若需具体文献支持，建议补充数据库检索结果。
The ZNF185 antibody targets the zinc finger protein 185 (ZNF185), a member of the LIM domain-containing protein family, which plays roles in cell adhesion, cytoskeletal organization, and signal transduction. ZNF185 is primarily expressed in tissues like the testis, kidney, and prostate, and shares homology with limbic system-associated membrane protein (LSAMP). It interacts with integrin-associated proteins, such as PINCH1. to regulate cell migration and proliferation.
Research on ZNF185 antibodies has focused on elucidating its involvement in cancer progression, particularly prostate and renal cancers, where altered expression correlates with metastasis and poor prognosis. These antibodies are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to detect ZNF185 localization and expression levels in clinical or experimental samples. Studies suggest ZNF185 may act as a tumor suppressor, with loss of expression linked to enhanced invasive behavior in cancer cells.
ZNF185 antibodies also aid in exploring its role in non-cancer pathologies, including kidney diseases, due to its renal expression. Their specificity enables investigations into ZNF185's structural domains, such as the LIM region critical for protein-protein interactions. However, variability in antibody performance across sample types necessitates validation for consistent experimental outcomes. Overall, ZNF185 antibodies remain vital tools for deciphering the protein's biological functions and therapeutic potential.
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