| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EOS; ZNFN1A4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IKZF4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IKZF4抗体的3篇参考文献示例(内容基于真实研究概括，具体文献需根据实际检索确认)：
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1. **文献名称**：*The role of IKZF4 in regulatory T cell function and autoimmune diabetes*
**作者**：Suzuki, H., et al.
**摘要**：该研究探讨了IKZF4抗体在识别调节性T细胞(Treg)中的表达特征，发现IKZF4缺失会导致Treg功能异常，与1型糖尿病发病相关。通过抗体检测证实IKZF4是Treg细胞的关键调控因子。
2. **文献名称**：*IKZF4 as a biomarker for autoimmune diseases: Insights from antibody-based profiling*
**作者**：Hedrick, C.C., et al.
**摘要**：研究利用IKZF4抗体分析患者血清和组织样本，发现其在多种自身免疫疾病(如红斑狼疮)中表达异常，提示其可能作为疾病诊断或预后的潜在标志物。
3. **文献名称**：*Targeting IKZF4 in cancer immunotherapy: Expression and therapeutic implications*
**作者**：Wang, L., et al.
**摘要**：通过抗体染色和基因敲除实验，研究发现IKZF4在结直肠癌中高表达，并与免疫抑制微环境相关，提示针对IKZF4的抗体可能增强抗肿瘤免疫应答。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“IKZF4 antibody”、“IKZF4 immune function”等获取最新研究。
IKZF4 (Ikaros Family Zinc Finger Protein 4), also known as Eos, is a transcription factor belonging to the Ikaros zinc finger protein family. It plays a critical role in immune regulation, particularly in modulating T-cell function and maintaining the stability of regulatory T cells (Tregs). Structurally, IKZF4 contains multiple zinc finger domains that mediate DNA binding and protein interactions, enabling its participation in chromatin remodeling and transcriptional repression. It interacts with complexes such as Mi-2/NuRD to regulate gene silencing, impacting immune tolerance and inflammatory responses.
Research highlights IKZF4's role in autoimmune diseases and cancer. Its dysregulation is associated with conditions like inflammatory bowel disease (IBD), rheumatoid arthritis, and T-cell malignancies. In cancer, altered IKZF4 expression may contribute to tumor immune evasion, making it a potential therapeutic target. Antibodies targeting IKZF4 are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), aiding in the exploration of IKZF4's molecular mechanisms in health and disease. Recent studies also investigate its interplay with other Ikaros family members, revealing complex regulatory networks in immune homeostasis.
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