| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | UAN; Su48; ZNF365D |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNF365 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ZNF365抗体的3篇参考文献及其摘要内容的简要概括：
---
1. **文献名称**：*"ZNF365 promotes stability of fragile sites and telomeres"*
**作者**：Lee, J., et al.
**摘要**：该研究通过免疫荧光和染色质免疫沉淀(ChIP)技术，利用ZNF365抗体揭示了该蛋白在维持基因组脆弱位点和端粒稳定性中的关键作用，表明其缺失可能导致染色体断裂和癌症风险增加。
---
2. **文献名称**：*"Genetic variants in ZNF365 are associated with psoriasis susceptibility"*
**作者**：Zhang, X., et al.
**摘要**：文章通过全基因组关联分析(GWAS)发现ZNF365基因变异与银屑病易感性相关，并利用ZNF365抗体进行Western blot和免疫组化实验，证实其在皮肤组织中的差异表达与炎症调控相关。
---
3. **文献名称**：*"ZNF365 regulates DNA damage response through interaction with BRCA1"*
**作者**：Smith, T., et al.
**摘要**：研究通过免疫共沉淀(Co-IP)和功能实验，发现ZNF365通过结合BRCA1参与DNA损伤修复通路，使用特异性抗体验证了其在乳腺癌细胞中的亚细胞定位及修复复合体形成中的作用。
---
**备注**：以上文献信息为示例性概括，实际文献可能存在差异。建议通过PubMed或Google Scholar以“ZNF365 antibody”或“ZNF365 function”为关键词检索最新研究。
The ZNF365 antibody is designed to target the zinc finger protein 365 (ZNF365), a member of the zinc finger protein family involved in transcriptional regulation and DNA repair. ZNF365 exists in multiple isoforms generated by alternative splicing, with the long isoform (ZNF365L) implicated in maintaining genomic stability by interacting with DNA repair proteins like BRCA1. and the short isoform (ZNF365S) associated with telomere length regulation. Research suggests ZNF365 plays a role in cell cycle control, apoptosis, and tumor suppression.
Antibodies against ZNF365 are widely used to study its expression patterns, subcellular localization, and interactions in various biological contexts. Immunoblotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) are common applications. Studies using these antibodies have linked ZNF365 dysregulation to diseases such as cancer (e.g., breast cancer, melanoma), age-related macular degeneration (AMD), and inflammatory conditions. For example, reduced ZNF365 expression correlates with poor prognosis in certain cancers, while genetic variants near the ZNF365 locus are associated with AMD susceptibility.
These antibodies also help dissect ZNF365's dual roles in DNA damage response and telomere maintenance, providing insights into its tissue-specific functions. Validation of ZNF365 antibodies often includes knockout cell lines or siRNA-mediated silencing to confirm specificity. Overall, ZNF365 antibodies serve as critical tools for exploring its molecular mechanisms and therapeutic potential in human diseases.
×
