Rabbit Polyclonal XPC Antibody

XPC antibody is a crucial tool in studying the XPC protein, a key component of the nucleotide excision repair (NER) pathway, which repairs bulky DNA lesions caused by UV radiation, environmental carcinogens, or chemotherapeutic agents. The XPC protein acts as a primary damage sensor in the global genome NER subpathway, initiating repair by recognizing DNA distortions and recruiting downstream repair factors. Mutations in the XPC gene are linked to xeroderma pigmentosum (XP), a rare autosomal recessive disorder characterized by extreme UV sensitivity, predisposition to skin cancers, and, in some cases, neurological abnormalities. XPC antibodies are widely used in research to detect and quantify XPC protein expression, assess its subcellular localization, and investigate interactions with other NER components (e.g., HR23B, TFIIH). These antibodies are essential for elucidating mechanisms of DNA damage recognition, repair efficiency, and genomic stability. They also aid in diagnosing XP variants and studying genotype-phenotype correlations. Commercially available XPC antibodies are typically developed in animal hosts (e.g., mouse, rabbit) using immunogenic peptide sequences or recombinant protein fragments. Validation methods include Western blotting, immunofluorescence, and immunohistochemistry, often using XPC-deficient cell lines as controls. Recent studies also explore XPC’s role beyond NER, such as in oxidative damage response and transcriptional regulation, further expanding the utility of XPC antibodies in both basic and clinical research.