Rabbit Polyclonal XKR4 Antibody

The XKR4 antibody targets the XK-related 4 (XKR4) protein, a member of the XK family of transmembrane proteins implicated in phospholipid scrambling and cellular apoptosis. XKR4. characterized by its eight transmembrane domains, is primarily associated with the externalization of phosphatidylserine (PS) on the cell surface during apoptosis—a critical signal for phagocytic cell recognition and clearance. While the molecular mechanisms of XKR4 remain under investigation, studies suggest it may function as a phospholipid scramblase, facilitating the redistribution of lipids across membranes in response to apoptotic stimuli. Dysregulation of XKR4 has been linked to pathologies such as cancer and neurodegenerative disorders, where defective apoptotic signaling contributes to disease progression. For instance, altered XKR4 expression has been observed in colorectal cancer and Alzheimer’s disease models, highlighting its potential role in cell survival and death pathways. Antibodies against XKR4 are widely used in research to study its localization, expression patterns, and interaction partners via techniques like Western blotting, immunohistochemistry, and flow cytometry. These tools have advanced understanding of XKR4's involvement in membrane dynamics, immune responses, and therapeutic targeting. However, functional studies remain challenging due to overlapping roles with other scramblases and limited structural data. Ongoing research aims to clarify its regulatory mechanisms and therapeutic potential in apoptosis-related diseases.