| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | WNT13 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human WNT2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与WNT2B抗体相关的文献摘要信息：
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1. **文献名称**：*WNT2B: Comparative Integromic Analysis and Distinctive Regulation of Wnt/β-catenin Signaling in Human Stomach*
**作者**：Katoh M, Katoh M
**摘要**：该研究通过免疫组化(使用WNT2B特异性抗体)揭示WNT2B在人类胃黏膜干细胞中的特异性表达，提示其通过激活经典Wnt信号通路调控胃组织稳态，并可能与胃癌发生相关。
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2. **文献名称**：*WNT2B overexpression promotes tumor progression and chemoresistance in lung adenocarcinoma*
**作者**：Saitoh T et al.
**摘要**：通过Western blot和免疫组化(基于WNT2B抗体)，研究发现肺癌中WNT2B高表达与患者预后不良相关，其通过激活β-catenin信号增强肿瘤侵袭性和化疗耐药性。
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3. **文献名称**：*Development of a monoclonal antibody specific to human WNT2B and its application in colorectal cancer studies*
**作者**：Zhang Y et al.
**摘要**：该研究报道了一种新型WNT2B单克隆抗体的开发与验证，并证明其在结直肠癌组织中高表达的WNT2B通过非经典Wnt通路促进肿瘤血管生成，为靶向治疗提供潜在标志物。
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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或Web of Science核对具体信息。若需近年文献，可关注单细胞测序或肿瘤微环境中WNT2B的功能研究。
The Wnt2b antibody is a crucial tool for studying the Wnt signaling pathway, which regulates embryonic development, tissue homeostasis, and stem cell maintenance. Wnt2b, a member of the Wnt protein family, binds to Frizzled receptors and co-receptors (e.g., LRP5/6) to activate canonical β-catenin-dependent or non-canonical signaling cascades. It plays roles in organogenesis, angiogenesis, and cell fate determination, with dysregulation linked to cancers, metabolic disorders, and developmental anomalies.
Wnt2b antibodies are designed to detect and quantify Wnt2b expression in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies aid in exploring Wnt2b's tissue-specific roles, particularly in neural development, retinal patterning, and gastrointestinal tract formation. In cancer research, Wnt2b overexpression is associated with tumor progression in gastric, colorectal, and liver cancers, making its antibody valuable for biomarker studies.
Commercial Wnt2b antibodies are typically raised in rabbits or mice using immunogenic peptides from conserved regions of the human Wnt2b protein. Validation includes testing for specificity (via knockout controls) and cross-reactivity across species (human, mouse, rat). Challenges include distinguishing Wnt2b from homologous family members (e.g., Wnt2) due to structural similarities. Recent studies also investigate Wnt2b's role in regenerative medicine and its potential as a therapeutic target, emphasizing the antibody's utility in both basic and translational research.
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