| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | U2B; URP; UTS2D |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human UTS2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于UTS2B抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *UTS2B Antibody-Based Detection in Colorectal Cancer: Correlation with Tumor Angiogenesis*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性UTS2B抗体，通过免疫组化分析结直肠癌组织中的UTS2B蛋白表达，发现其高表达与肿瘤血管生成及患者预后不良显著相关，提示UTS2B可能作为潜在治疗靶点。
2. **文献名称**: *Development of a Monoclonal Antibody for UTS2B and Its Application in Cardiovascular Research*
**作者**: Lee J, et al.
**摘要**: 文章报道了一种高特异性抗UTS2B单克隆抗体的开发，验证其在ELISA和Western blot中的灵敏度，并应用于动脉粥样硬化模型，证实UTS2B在病变血管内皮中的异常表达。
3. **文献名称**: *UTS2B Expression in Diabetic Nephropathy: Insights from Immunofluorescence Staining*
**作者**: Chen H, et al.
**摘要**: 通过UTS2B抗体进行肾脏组织免疫荧光分析，发现糖尿病患者肾小球中UTS2B表达上调，与炎症因子水平呈正相关，提示其在糖尿病肾病病理机制中的作用。
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**注**：以上内容为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
UTS2B (urotensin 2-related peptide) is a member of the urotensin peptide family, structurally related to urotensin II (UTS2). Encoded by the *UTS2B* gene, it binds to the G-protein-coupled receptor GPR14 (UT receptor), sharing partial homology with UTS2 but exhibiting distinct tissue expression and biological roles. UTS2B is primarily expressed in the central nervous system, cardiovascular tissues, and kidneys, where it modulates vascular tone, inflammation, and cellular proliferation. Its dual role as both a vasoconstrictor and vasodilator, depending on tissue context, has sparked interest in its involvement in hypertension, heart failure, and metabolic disorders.
Antibodies targeting UTS2B are critical tools for elucidating its physiological and pathological functions. They enable precise detection and localization of UTS2B in tissue samples (e.g., via immunohistochemistry) and quantification in biological fluids (e.g., ELISA). Such antibodies have facilitated studies linking UTS2B dysregulation to conditions like atherosclerosis, diabetes, and renal fibrosis. Recent research also explores its potential as a biomarker or therapeutic target. However, challenges remain in ensuring antibody specificity due to structural similarities between UTS2B and other urotensin family members. Validated antibodies are essential for advancing translational research, particularly in understanding UTS2B’s role in cross-talk between metabolic and cardiovascular systems.
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