Rabbit Polyclonal NUP98 Antibody

The NUP98 antibody is a crucial tool for studying the NUP98 protein, a component of the nuclear pore complex (NPC) that regulates nucleocytoplasmic transport. NUP98. encoded by the *NUP98* gene, is part of the nucleoporin family and plays roles in mRNA export, gene regulation, and chromatin organization. Its significance in disease stems from recurrent chromosomal translocations in hematologic malignancies, particularly acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). These translocations fuse the N-terminal region of *NUP98* to various partner genes (e.g., *HOXA9*, *HOXD13*), generating oncogenic fusion proteins that disrupt transcriptional regulation and cellular differentiation. NUP98 antibodies are essential for detecting these fusion proteins, studying their localization, and understanding their oncogenic mechanisms. Additionally, NUP98 mutations or rearrangements are linked to therapeutic resistance, making these antibodies valuable in both research and clinical diagnostics. They are used in techniques like Western blotting, immunofluorescence, immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) to identify aberrant NUP98 expression or fusion events. Commercially available clones vary in specificity, often targeting epitopes within the N-terminal (common in fusion detection) or C-terminal regions. Research using NUP98 antibodies continues to unravel its roles in nuclear transport, leukemogenesis, and potential therapeutic targeting.