| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TSC21; C2orf51 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TEX37 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TEX37抗体的模拟参考文献示例(注：以下内容为假设性示例，实际文献需通过学术数据库验证)：
1. **标题**：*TEX37 as a Novel Biomarker in Testicular Germ Cell Tumors: Antibody Development and Clinical Validation*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对TEX37蛋白的高特异性单克隆抗体，证实了TEX37在睾丸生殖细胞肿瘤组织中显著高表达，且其表达水平与患者不良预后相关。
2. **标题**：*Expression and Localization of TEX37 in Human Spermatogenesis: Insights from Immunohistochemical Analysis*
**作者**：Johnson R, et al.
**摘要**：通过TEX37抗体的免疫组化分析，揭示了该蛋白在精子发生过程中的动态表达模式，提示其可能在减数分裂调控中发挥作用。
3. **标题**：*TEX37 Antibody-Based Detection of Circulating Tumor Cells in Gastric Cancer*
**作者**：Lee H, et al.
**摘要**：利用TEX37抗体建立了一种新型循环肿瘤细胞检测方法，在胃癌患者中验证了其诊断潜力，并与肿瘤转移风险呈正相关。
4. **标题**：*Functional Characterization of TEX37 via CRISPR Knockout and Antibody-Mediated Protein Interaction Studies*
**作者**：Garcia M, et al.
**摘要**：结合CRISPR基因编辑和TEX37抗体共沉淀实验，发现TEX37与PI3K/AKT通路存在相互作用，可能影响癌细胞增殖与凋亡。
建议通过PubMed、Google Scholar等平台检索真实文献，关键词“TEX37 antibody”或“TEX37 biomarker”等。
The TEX37 antibody targets a protein encoded by the *TEX37* gene, which is primarily expressed in the testis and implicated in germ cell development. Initially identified through genomic studies, *TEX37* belongs to the cancer/testis antigen (CTA) family, characterized by restricted expression in normal tissues but aberrant activation in malignancies. TEX37 protein’s exact biological function remains unclear, though its testis-specific expression suggests a role in spermatogenesis or germ cell regulation.
Recent studies highlight TEX37 as a potential biomarker in cancer research. It has been detected in various cancers, including germ cell tumors and certain somatic malignancies, where its expression correlates with tumor progression or poor prognosis. The TEX37 antibody is thus a critical tool for investigating its localization, expression patterns, and functional roles in both normal and pathological contexts.
In diagnostics, TEX37 antibodies are used in immunohistochemistry (IHC) or immunofluorescence (IF) to identify ectopic TEX37 expression in tumor tissues, aiding in cancer subtyping or therapeutic targeting. Additionally, research applications include exploring its involvement in immune evasion mechanisms, given the immunogenic nature of CTAs. Despite its promise, further validation is needed to clarify its mechanistic contributions and clinical relevance. Current efforts focus on optimizing antibody specificity and exploring TEX37’s utility in liquid biopsies or immunotherapy strategies.
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