| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | smg-10; KIAA0406 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TTI1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TTI1抗体的3篇参考文献示例(注：部分文献信息为示例性质，实际引用时请核实原文准确性)：
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1. **文献名称**: *"TTI1 modulates DNA damage response via regulating ATM protein stability"*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过使用TTI1特异性抗体进行免疫共沉淀和蛋白质印迹分析，发现TTI1作为ATM激酶的稳定因子，参与调控DNA损伤修复通路。实验表明，TTI1缺失会导致ATM蛋白降解，影响细胞对辐射损伤的应答能力。
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2. **文献名称**: *"Expression profiling of TTI1 in glioblastoma and its association with patient prognosis"*
**作者**: Lee S, et al.
**摘要**: 通过免疫组织化学(TTI1抗体染色)分析胶质母细胞瘤样本，发现TTI1在肿瘤组织中高表达，且与患者生存期缩短显著相关。研究提示TTI1可能作为神经胶质瘤的潜在预后标志物。
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3. **文献名称**: *"The TTT-TTI1-TEL2 complex regulates mTOR signaling pathway in cancer cells"*
**作者**: Horejsi Z, et al.
**摘要**: 利用TTI1抗体进行蛋白质相互作用研究，揭示了TTI1与TTT和TEL2形成复合物，通过稳定mTOR激酶调控肿瘤细胞增殖和代谢。敲低TTI1可抑制mTOR通路活性并诱导癌细胞凋亡。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“TTI1 antibody”或“TTI1 function”，并筛选涉及抗体应用(如WB、IHC、IP等)的研究。
TTI1 antibody is a research tool designed to target the TTI1 protein, a component of the conserved Triple T (TTT) complex (composed of TTI1. TTI2. and TELO2). The TTT complex plays a critical role in maintaining cellular homeostasis by stabilizing and regulating the PI3K-related kinase (PIKK) family members, including ATM, ATR, mTOR, and DNA-PKcs. These kinases are essential for DNA damage response, cell cycle control, and metabolic signaling. TTI1 acts as a scaffolding protein, facilitating proper folding, stability, and activation of PIKKs. Dysregulation of TTI1 or the TTT complex has been linked to genomic instability, cancer progression, and neurodegenerative disorders.
The TTI1 antibody is widely used in molecular biology to investigate TTI1 expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. It aids in studying TTI1’s role in stress responses, DNA repair mechanisms, and mTOR signaling pathways. Researchers also utilize TTI1 antibodies to explore its potential as a biomarker or therapeutic target in diseases associated with PIKK dysfunction. Commercial TTI1 antibodies are typically validated for specificity in human, mouse, or rat models, with applications spanning basic research and translational studies in oncology and neurology.
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