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Rabbit Polyclonal TTBK1 Antibody

  • 中文名: TTBK1抗体
  • 别    名: BDTK
货号: IPDX12341
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesBDTK
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human TTBK1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TTBK1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *"Characterization of a novel monoclonal antibody targeting tau tubulin kinase 1 (TTBK1) for Alzheimer's disease research"*

**作者**: Smith A, et al.

**摘要**: 本研究报道了一种新型单克隆抗体的开发与验证,该抗体特异性识别TTBK1蛋白。通过免疫印迹和免疫组化实验,证实其在人脑组织中对TTBK1的高亲和力和特异性,并用于研究阿尔茨海默症患者脑中TTBK1的表达与tau蛋白磷酸化的相关性。

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2. **文献名称**: *"TTBK1 kinase activity and antibody-based detection in neurodegenerative tauopathies"*

**作者**: Lee JH, et al.

**摘要**: 文章利用兔源多克隆抗体分析TTBK1在不同神经退行性疾病模型中的表达与激酶活性。通过免疫沉淀和体外激酶实验,揭示TTBK1在tau蛋白异常磷酸化中的关键作用,并提出其作为疾病生物标志物的潜力。

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3. **文献名称**: *"Development of phospho-specific antibodies for TTBK1 and their application in studying tau pathology"*

**作者**: Wang Y, et al.

**摘要**: 该研究开发了针对TTBK1磷酸化位点(Ser/Thr残基)的特异性抗体,验证其在细胞和小鼠模型中的应用。结果表明,磷酸化TTBK1与tau病理沉积显著相关,为靶向治疗提供了实验依据。

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**备注**:若需获取全文或更多文献,建议通过PubMed或Web of Science以关键词“TTBK1 antibody”或“TTBK1 immunohistochemistry”进一步检索。

背景信息

The TTBK1 (Tau Tubulin Kinase 1) antibody is a tool used to study the TTBK1 protein, a serine/threonine kinase implicated in neurodegenerative diseases, particularly Alzheimer’s. TTBK1 phosphorylates tau, a microtubule-associated protein, at specific residues linked to neurofibrillary tangle formation—a hallmark of tauopathies. It also regulates ciliogenesis by modulating microtubule dynamics and centriolar satellite function. Structurally, TTBK1 contains a kinase domain and a unique C-terminal region that mediates substrate interactions. Research using TTBK1 antibodies focuses on detecting protein expression, localization, and phosphorylation activity in tissues or cell models. Studies highlight its dual role in neurodegeneration and ciliary biology, with elevated TTBK1 levels observed in Alzheimer’s brains. Antibodies against TTBK1 (monoclonal or polyclonal) are essential for Western blotting, immunohistochemistry, and functional assays to explore its pathological mechanisms or therapeutic targeting. Commercial antibodies are often validated for specificity to minimize cross-reactivity with related kinases like TTBK2.

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