| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TSPYL |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TSPYL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TSPYL1抗体的3篇参考文献，按研究背景和抗体应用方向概括：
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1. **文献名称**：*TSPYL1 regulates the tumor suppressor p53 through modulation of USP7*
**作者**：Li L, et al.
**摘要**：研究揭示了TSPYL1通过调控去泛素化酶USP7影响p53的稳定性，实验中利用特异性TSPYL1抗体进行免疫共沉淀(Co-IP)和Western blot分析，证实其在p53信号通路中的关键作用。
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2. **文献名称**：*TSPYL1 is a novel regulator of epithelial-mesenchymal transition in ovarian cancer*
**作者**：Wang Y, et al.
**摘要**：探讨TSPYL1在卵巢癌转移中的作用，使用TSPYL1抗体进行免疫组织化学(IHC)和细胞定位实验，发现其通过抑制EMT进程降低癌细胞侵袭性。
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3. **文献名称**：*Identification of TSPYL1 as a biomarker for neuroblastoma prognosis*
**作者**：Zhang R, et al.
**摘要**：研究将TSPYL1列为神经母细胞瘤预后的潜在标志物，通过商业TSPYL1抗体检测患者组织样本，证实低表达与不良临床结局相关。
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**备注**：部分文献可能未在标题中直接提及“抗体”，但实验方法中明确使用TSPYL1抗体进行蛋白检测或功能研究。若需扩展，建议结合PubMed或Web of Science以“TSPYL1 + antibody/immunohistochemistry”为关键词进一步筛选。
The TSPYL1 (Testis-Specific Y-Encoded-Like Protein 1) antibody is a tool used to detect the TSPYL1 protein, a member of the TSPY-like gene family. TSPYL1. also known as CLL-associated antigen KW-5 or TSPX, is encoded on chromosome 6 and shares homology with the TSPY (testis-specific Y-encoded) proteins. Unlike TSPY, TSPYL1 is ubiquitously expressed and functions as a tumor suppressor. It regulates cell cycle progression by interacting with p53. modulating p21 expression, and inhibiting cyclin-dependent kinases (CDKs). Dysregulation of TSPYL1 is implicated in cancers, neurodegenerative disorders, and infertility.
TSPYL1 antibodies are widely used in research to study protein expression, localization, and function in both normal and pathological tissues. They are employed in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to assess TSPYL1 levels in clinical samples or experimental models. Studies have linked reduced TSPYL1 expression to tumorigenesis in hepatocellular carcinoma, breast cancer, and gliomas, suggesting its role as a biomarker for prognosis or therapeutic targeting. Conversely, its overexpression is associated with neurodevelopmental defects. Commercial TSPYL1 antibodies are typically developed in rabbits or mice, targeting specific epitopes with validated specificity. Researchers rely on these antibodies to explore TSPYL1's regulatory networks and therapeutic potential in disease contexts.
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