| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | DTDP1; SMAP2; MST117; MSTP117; MSTP140; bA37D8.1; bA270C4A.1; dJ421D16.1 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SMOC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SMOC2抗体的3篇参考文献示例(部分信息基于假设性内容整理，实际文献需通过学术数据库验证)：
---
1. **文献名称**: *"A monoclonal antibody targeting SMOC2 inhibits tumor growth in pancreatic cancer models"*
**作者**: Li, Y., et al.
**摘要**: 本研究开发了一种针对SMOC2的小鼠单克隆抗体，验证了其在胰腺癌组织中的特异性结合能力。实验表明，该抗体可通过阻断SMOC2与整合素相互作用抑制肿瘤细胞迁移和体内肿瘤生长。
2. **文献名称**: *"SMOC2 expression in cardiac fibrosis: Validation of a custom polyclonal antibody for immunohistochemistry"*
**作者**: Garcia-Ramirez, M., et al.
**摘要**: 作者制备并验证了一种兔源多克隆抗体，用于检测心脏纤维化模型中的SMOC2蛋白。抗体在免疫组化(IHC)和免疫印迹(WB)中表现出高特异性，证实SMOC2在纤维化区域显著上调。
3. **文献名称**: *"Development of a sensitive ELISA for SMOC2 detection in serum using a novel antibody pair"*
**作者**: Watanabe, K., et al.
**摘要**: 研究团队筛选出针对SMOC2不同表位的单克隆抗体，并建立了一种高灵敏度的ELISA检测方法。该抗体对能够检测血清中低浓度的SMOC2.为癌症早期诊断提供了潜在工具。
---
**提示**：以上为示例性内容，实际文献需通过PubMed、Web of Science等平台检索。建议使用关键词“SMOC2 antibody”、“SMOC2 immunoassay”或结合具体应用场景(如“SMOC2 cancer”)查找近期研究。部分商业抗体的验证数据也可参考供应商网站(如Abcam、Sigma-Aldrich的产品说明书引用文献)。
SMOC2 (Secreted Modular Calcium-Binding Protein 2) is a member of the SPARC (Secreted Protein Acidic and Rich in Cysteine) family, characterized by its modular structure containing follistatin-like and calcium-binding domains. It is expressed in various tissues and plays roles in extracellular matrix (ECM) organization, cell adhesion, and tissue development. SMOC2 is implicated in regulating cellular processes such as proliferation, differentiation, and angiogenesis through interactions with growth factors (e.g., BMPs) and integrin-mediated signaling pathways.
Antibodies targeting SMOC2 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect SMOC2 in tissue samples or cell cultures. Research has linked SMOC2 overexpression to diseases such as cancer (e.g., promoting tumor progression and metastasis in colorectal, liver, and breast cancers) and fibrotic disorders (e.g., liver and lung fibrosis). Its role in embryonic development, particularly in organogenesis and tissue repair, also makes it a focus in regenerative medicine studies. SMOC2 antibodies aid in elucidating its dual roles in ECM homeostasis and disease mechanisms, offering potential as a biomarker or therapeutic target. Most commercial SMOC2 antibodies are raised against specific epitopes using recombinant proteins or synthetic peptides, validated for species reactivity (human, mouse, rat) and application-specific performance.
×
