| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Hkp1; mtTFB2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TFB2M |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TFB2M抗体的3篇示例参考文献(注：文献为示例性质，建议通过学术数据库进一步验证)：
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1. **文献名称**: "TFB2M is essential for mitochondrial DNA transcription and respiratory chain assembly"
**作者**: Smith, J.D. et al.
**摘要**: 本研究利用特异性TFB2M抗体(通过兔多克隆免疫制备)，揭示了TFB2M在线粒体DNA转录及呼吸链复合物组装中的核心作用。通过敲低实验和Western blot分析，证实其缺失导致线粒体功能严重受损。
2. **文献名称**: "Development of a monoclonal antibody against human TFB2M for cancer biomarker studies"
**作者**: Zhang, L. et al.
**摘要**: 文章报道了一种新型小鼠源单克隆TFB2M抗体的开发，并验证其在免疫组化(IHC)和流式细胞术中的应用。研究发现，TFB2M在多种癌症组织中高表达，可能作为潜在代谢相关肿瘤标志物。
3. **文献名称**: "TFB2M deficiency in Parkinson’s disease models: Insights from antibody-based proteomic analysis"
**作者**: Lee, S. et al.
**摘要**: 通过商业化TFB2M抗体(货号AB123.公司X)进行蛋白质组学分析，发现帕金森病模型中TFB2M表达显著降低，并与其线粒体自噬功能障碍相关，提示其作为神经退行性疾病治疗靶点的潜力。
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**注意**：以上文献信息为模拟示例，实际引用需以真实数据库(如PubMed、Web of Science)检索结果为准。建议结合关键词“TFB2M antibody”、“mitochondrial transcription”等进一步筛选。
TFB2M (Transcription Factor B2. Mitochondrial) is a nuclear-encoded protein critical for mitochondrial gene expression and function. It plays a key role in mitochondrial DNA (mtDNA) transcription and RNA modification. TFB2M forms part of the mitochondrial transcription complex alongside mitochondrial RNA polymerase (POLRMT) and transcription factor A (TFAM). It facilitates promoter recognition and stabilizes the initiation of mtDNA transcription. Additionally, TFB2M is involved in ribosomal RNA (rRNA) methylation, contributing to the assembly and function of mitochondrial ribosomes, essential for oxidative phosphorylation (OXPHOS) and cellular energy production.
Antibodies targeting TFB2M are vital tools for studying mitochondrial biology, particularly in contexts like mitochondrial disorders, cancer, and neurodegenerative diseases. Dysregulation of TFB2M has been linked to impaired mitochondrial respiration, altered metabolism, and apoptosis. In research, TFB2M antibodies enable the detection of protein expression levels via Western blotting, immunohistochemistry, or immunofluorescence, aiding investigations into mitochondrial dysfunction. They also help elucidate interactions within mitochondrial transcription complexes or assess post-translational modifications. Clinically, TFB2M expression patterns may serve as biomarkers for diseases such as Alzheimer’s, Parkinson’s, or certain cancers. Furthermore, these antibodies support drug discovery efforts targeting mitochondrial pathways. By probing TFB2M’s role in health and disease, researchers aim to uncover therapeutic strategies for conditions tied to mitochondrial failure.
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