| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | E25; BRI3; E25C; ITM3; BRICD2C |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ITM2C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITM2C抗体的参考文献示例(内容基于假设性研究，建议核实实际文献)：
1. **文献名称**：*ITM2C regulates amyloid-beta protein precursor processing through a novel lysosomal pathway*
**作者**：Smith A, et al.
**摘要**：研究利用特异性ITM2C抗体，通过免疫印迹和免疫荧光技术，揭示ITM2C在阿尔茨海默病模型中调控淀粉样前体蛋白(APP)裂解的作用，提示其与β-淀粉样蛋白沉积相关。
2. **文献名称**：*Antibody-based profiling of ITM2C in neuronal development and differentiation*
**作者**：Jones B, et al.
**摘要**：通过开发多克隆ITM2C抗体，发现ITM2C在小鼠神经元分化过程中的动态表达，免疫组化显示其定位于内质网，可能参与神经突触形成。
3. **文献名称**：*Monoclonal antibody generation for ITM2C and its application in cancer biomarker discovery*
**作者**：Chen L, et al.
**摘要**：报道一种高特异性抗ITM2C单克隆抗体的制备，并用于检测多种肿瘤组织中ITM2C的异常表达，提示其作为胶质瘤潜在生物标志物的价值。
4. **文献名称**：*ITM2C interacts with BRI2 in familial dementia: Insights from co-immunoprecipitation assays*
**作者**：Wang X, et al.
**摘要**：利用ITM2C抗体进行免疫共沉淀实验，证实ITM2C与痴呆相关蛋白BRI2的相互作用，为遗传性痴呆的分子机制提供新证据。
(注：以上为模拟文献，实际引用时请通过PubMed或Google Scholar检索真实论文。)
The ITM2C (Integral Membrane Protein 2C) antibody targets a protein encoded by the *ITM2C* gene, which belongs to the ITM2 family of type II transmembrane proteins. These proteins share a conserved BRICHOS domain, implicated in protein folding and quality control. ITM2C is predominantly expressed in the central nervous system, particularly in neurons and glial cells, suggesting roles in neural development, maintenance, or synaptic function. It has been linked to neurodegenerative processes, including Alzheimer's disease (AD), due to its interaction with BRI2 (also known as ITM2B), a protein involved in regulating amyloid precursor protein (APP) processing and amyloid-beta (Aβ) production. Dysregulation of ITM2C may contribute to Aβ accumulation, a hallmark of AD pathology.
ITM2C antibodies are essential tools for detecting and studying the protein's expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ITM2C's tissue distribution, cellular trafficking, and interaction partners. Research applications also extend to exploring its potential role in cancer, as aberrant ITM2C expression has been observed in certain malignancies. These antibodies aid in elucidating molecular mechanisms underlying neurodegenerative diseases and malignancies, offering insights into therapeutic targets. Validation of ITM2C antibodies ensures specificity for accurate experimental outcomes, particularly in complex biological systems like brain tissue.
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