Rabbit Polyclonal TAFA4 Antibody

TAFA4. a member of the TAFA (TAFA chemokine-like family) protein family, is a secreted glycoprotein predominantly expressed in small-diameter sensory neurons of the dorsal root ganglia (DRG). Discovered in the early 2000s, TAFA4 is structurally related to the MIP-1α/CCL3 chemokine family but lacks classical chemokine receptor-binding motifs. It plays a role in modulating sensory neuron activity and neuro-immune interactions, particularly in pain and inflammatory pathways. Studies suggest TAFA4 acts as a negative regulator of mechanical pain sensitivity, influencing synaptic plasticity and neuronal survival through interactions with undefined receptors. Its expression is upregulated in response to nerve injury and inflammation, implicating it in tissue repair and chronic pain conditions. TAFA4 antibodies, developed for research and therapeutic exploration, are used to neutralize TAFA4 activity, enabling mechanistic studies in pain models and inflammatory diseases. Recent work highlights its potential as a biomarker or therapeutic target for neuropathic pain and neuroinflammatory disorders, though its precise signaling mechanisms remain under investigation. These antibodies have become critical tools in dissecting TAFA4’s dual roles in nociception and neuroprotection.