Rabbit Polyclonal GPKOW Antibody

The GPKOW antibody is designed to target the GPKOW protein, also known as SPF30 or SPF45. a conserved RNA-binding protein involved in transcriptional regulation and pre-mRNA splicing. GPKOW contains a G-patch domain, which mediates interactions with RNA or other proteins, and KOW motifs that facilitate RNA or protein binding. It plays a role in spliceosome assembly and dynamics, contributing to splice site selection and splicing efficiency. Studies suggest GPKOW associates with RNA polymerase II and the U5 snRNP complex, linking transcription and splicing. Dysregulation of GPKOW has been implicated in cancers and neurodegenerative diseases, where aberrant splicing contributes to pathogenesis. The GPKOW antibody is widely used in molecular biology to detect protein expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Its development aids in exploring GPKOW's functional mechanisms, spliceosome architecture, and disease-related splicing errors. Recent research highlights its potential as a biomarker or therapeutic target in conditions linked to splicing defects. Validated for specificity in model organisms and human cells, this antibody remains a critical tool for studying RNA processing and gene expression regulation.