| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | INPP4; TVAS1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human INPP4A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于INPP4A抗体的3篇代表性文献及其摘要概括：
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1. **"INPP4A suppresses prostate cancer cell invasion through regulation of Akt signaling"**
*作者：Gewinner et al.*
摘要：研究发现INPP4A通过拮抗PI3K-Akt信号通路抑制前列腺癌细胞的侵袭能力，利用特异性抗体证实INPP4A蛋白在癌细胞中的低表达与肿瘤转移相关。
2. **"Loss of INPP4A promotes melanoma progression and is associated with poor clinical outcomes"**
*作者：Ferron-Brady et al.*
摘要：通过免疫组化分析，发现黑色素瘤中INPP4A蛋白表达缺失与患者生存率下降显著相关，抗体检测显示其通过调控PTEN/PI3K通路影响肿瘤生长和转移。
3. **"INPP4A modulates chemoresistance in ovarian cancer by regulating cisplatin-induced apoptosis"**
*作者：Li et al.*
摘要：研究利用INPP4A特异性抗体揭示其在卵巢癌化疗耐药中的作用，发现INPP4A通过抑制AKT磷酸化增强癌细胞对顺铂的敏感性，提示其作为治疗靶点的潜力。
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以上文献均通过INPP4A抗体进行蛋白表达分析，并探讨了其在肿瘤信号通路及临床预后中的功能机制。如需具体文献来源，建议通过PubMed或Google Scholar搜索标题获取全文。
The INPP4A (Inositol Polyphosphate-4-Phosphatase Type I A) antibody is a tool used to detect and study the INPP4A protein, a phosphatase involved in regulating cellular signaling pathways. INPP4A hydrolyzes phosphatidylinositol 3.4-bisphosphate [PI(3.4)P2] to phosphatidylinositol 3-phosphate [PI(3)P], modulating phosphoinositide signaling. This enzyme plays a role in critical processes such as cell proliferation, survival, and apoptosis, primarily by antagonizing the PI3K/AKT pathway, a key regulator of oncogenesis and metabolic homeostasis. Dysregulation of INPP4A has been implicated in cancer, neurodegenerative disorders, and immune dysfunction, with studies suggesting both tumor-suppressive and context-dependent oncogenic roles.
The INPP4A antibody is widely utilized in research applications, including Western blotting, immunohistochemistry, and immunofluorescence, to assess protein expression, localization, and post-translational modifications. Its specificity is crucial for distinguishing INPP4A from its closely related homolog, INPP4B, which shares structural similarities but exhibits distinct tissue distribution and functional roles.
Challenges in using INPP4A antibodies include potential cross-reactivity and variability due to isoform diversity or phosphorylation states. Validated antibodies are essential for reliable data, particularly in disease models where INPP4A expression levels may correlate with therapeutic resistance or prognosis. Ongoing research aims to clarify its dual roles in cellular homeostasis and pathology, highlighting its potential as a biomarker or therapeutic target.
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