| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | coaC; MDS018; PPC-DC |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为假设性示例的参考文献(仅供参考，建议通过学术数据库查询最新文献)：
1. **文献名称**: "Development and characterization of a monoclonal antibody targeting human phosphopantothenoylcysteine decarboxylase (PPCDC) for functional studies"
**作者**: Smith A, et al.
**摘要**: 本研究报道了一种针对人源PPCDC蛋白的单克隆抗体的开发与验证。通过免疫印迹和免疫荧光证实该抗体特异性识别PPCDC，并应用于探究其在辅酶A合成通路中的作用及与代谢疾病的潜在关联。
2. **文献名称**: "PPCDC expression profiling in cancer cells using a novel polyclonal antibody: implications for tumor metabolism"
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种兔源多克隆抗体，用于检测多种癌细胞系中PPCDC的表达水平。结果显示PPCDC在快速增殖的肿瘤细胞中显著上调，提示其可能作为癌症代谢重编程的生物标志物。
3. **文献名称**: "Structural insights into PPCDC enzyme complex through antibody-mediated crystallization"
**作者**: Yamamoto K, et al.
**摘要**: 利用特异性抗体辅助获得PPCDC与其辅因子的复合物晶体结构，揭示了该酶催化机制的关键构象变化，为靶向PPCDC的药物设计提供了结构基础。
4. **文献名称**: "A PPCDC-specific antibody library for high-throughput screening in bacterial and mammalian systems"
**作者**: Patel R, et al.
**摘要**: 构建了针对PPCDC不同表位的抗体库，验证了其在原核和真核表达系统中的兼容性，为大规模筛选PPCDC功能抑制剂及相互作用蛋白提供了工具。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索确认。建议结合具体研究背景补充关键词(如疾病类型、实验模型等)以提高检索效率。
PPCDC (phosphopantothenoylcysteine decarboxylase) antibodies are tools used to study the enzyme critical for coenzyme A (CoA) biosynthesis. PPCDC catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in CoA production. CoA is essential for cellular metabolism, including fatty acid synthesis, energy production, and acetylation reactions. Dysregulation of PPCDC has been linked to metabolic disorders, cancer, and neurodegenerative diseases.
Antibodies targeting PPCDC enable researchers to detect its expression, localization, and activity in tissues or cell lines. They are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate PPCDC's role in diseases. For example, elevated PPCDC levels have been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target. In metabolic studies, these antibodies help dissect CoA-related pathways and their implications in conditions like diabetes or mitochondrial dysfunction.
Recent studies also explore PPCDC inhibitors for anticancer strategies, leveraging its role in cancer cell proliferation. Additionally, PPCDC antibodies aid in validating gene knockdown/knockout models to study CoA deficiency syndromes. Their application spans basic research, drug development, and diagnostic exploration, emphasizing PPCDC's multifaceted impact on cellular health and disease mechanisms.
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