| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GdA; GdF; GdS; Glycodelin A; Glycodelin; Glycodelin F; Glycodelin S; PAEG; PAEP; PEG; PEP; Placental protein 14; PP14;;Glycodelin |
| WB Predicted band size | Calculated MW: 21 kDa ; Observed MW: 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Glycodelin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇涉及CDCA4抗体的研究文献概览：
---
1. **文献名称**：*CDCA4 regulates proliferation in bladder cancer via the CDK2 signaling pathway*
**作者**：Li Y, et al.
**摘要**：研究通过Western blot和免疫组化使用CDCA4抗体，证明CDCA4在膀胱癌中通过调控CDK2表达促进肿瘤细胞增殖，提示其作为潜在治疗靶点。
---
2. **文献名称**：*The role of CDCA4 in hepatocellular carcinoma progression and its clinical significance*
**作者**：Wang X, et al.
**摘要**：利用CDCA4特异性抗体进行免疫荧光染色，发现CDCA4在肝癌组织中高表达，并通过PI3K/AKT通路影响肿瘤转移，与患者预后不良相关。
---
3. **文献名称**：*CDCA4 interacts with E2F1 to regulate DNA damage response in breast cancer cells*
**作者**：Zhang H, et al.
**摘要**：通过免疫共沉淀(Co-IP)结合CDCA4抗体，揭示CDCA4与转录因子E2F1互作，调控乳腺癌细胞对化疗的DNA损伤应答机制。
---
4. **文献名称**：*CDCA4 as a novel biomarker for early-stage lung adenocarcinoma*
**作者**：Chen L, et al.
**摘要**：采用CDCA4多克隆抗体进行组织芯片分析，发现CDCA4在肺腺癌早期高表达，可作为诊断标志物，并通过siRNA验证其促癌功能。
---
注：以上文献信息为示例，实际引用需根据具体论文核实。建议通过PubMed或Google Scholar以“CDCA4 antibody”+“应用场景”(如Western blot/cancer)检索最新研究。
**Background of CDCA4 Antibody**
CDCA4 (Cell Division Cycle Associated 4), also known as SEI3 or LURAP1. is a protein implicated in cell cycle regulation and transcriptional control. It interacts with the E2F transcription factor family, playing a role in the transition from G1 to S phase by modulating chromatin remodeling and DNA replication. CDCA4 is involved in the anaphase-promoting complex/cyclosome (APC/C) pathway, contributing to cell cycle progression and genomic stability.
CDCA4 antibodies are tools used to detect and study the expression, localization, and function of the CDCA4 protein in various biological contexts. These antibodies are widely applied in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Research has highlighted CDCA4's association with cancer, where its dysregulation is linked to tumorigenesis, metastasis, and poor prognosis in cancers such as hepatocellular carcinoma, breast cancer, and glioblastoma.
Studies using CDCA4 antibodies have also explored its role in stem cell differentiation, DNA damage response, and therapeutic resistance. The development of specific and validated CDCA4 antibodies remains critical for advancing mechanistic insights into its biological functions and potential as a diagnostic or therapeutic target in diseases.
×
