| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UNC5H3 |
| WB Predicted band size | 103 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human UNC5C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UNC5C抗体的3篇代表性文献示例(文献信息为模拟，供参考)：
1. **文献名称**: "UNC5C mediates apoptosis in neuroblastoma through Netrin-1 signaling"
**作者**: Smith A, et al.
**摘要**: 研究利用UNC5C抗体检测神经母细胞瘤中受体表达，证实UNC5C通过Netrin-1依赖的凋亡通路抑制肿瘤生长，提示其作为潜在治疗靶点。
2. **文献名称**: "Epigenetic silencing of UNC5C promotes colorectal cancer metastasis"
**作者**: Li Y, et al.
**摘要**: 通过UNC5C抗体进行免疫组化和Western blot分析，发现结直肠癌中UNC5C表达因DNA甲基化下调，与患者转移和预后不良相关。
3. **文献名称**: "UNC5C regulates axon guidance via interaction with DCC receptor"
**作者**: Gomez CC, et al.
**摘要**: 利用UNC5C特异性抗体进行共聚焦显微镜观察，揭示UNC5C与DCC受体在神经元轴突导向中的协同作用，为神经发育机制提供新证据。
注：以上文献为示例，实际引用需根据具体研究通过学术数据库(如PubMed)检索核实。UNC5C抗体相关研究多集中于神经发育、癌症及凋亡领域。
The UNC5C antibody is a crucial tool for studying the UNC5C receptor, a member of the UNC5 family of netrin receptors involved in neural development and cancer biology. UNC5C, encoded by the *UNC5C* gene, acts as a dependence receptor that induces apoptosis in the absence of its ligand netrin-1. playing dual roles in cell survival and death. Structurally, it contains extracellular immunoglobulin (Ig) and thrombospondin type 1 (TSP1) domains for ligand binding, a transmembrane region, and a cytoplasmic death domain critical for pro-apoptotic signaling.
Research highlights UNC5C's involvement in axon guidance, neuronal migration, and vascular patterning during development. In cancer, UNC5C often functions as a tumor suppressor, with its silencing or mutation linked to colorectal, breast, and pancreatic cancers. Dysregulation of UNC5C-netrin signaling is also implicated in neurodegenerative diseases like Alzheimer’s.
UNC5C antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and post-translational modifications. These antibodies help elucidate UNC5C's role in disease mechanisms and its potential as a therapeutic target. When selecting an UNC5C antibody, validation for specificity (e.g., using knockout controls) and compatibility with the experimental model (human, mouse) is essential. Both monoclonal and polyclonal variants are available, targeting distinct epitopes to accommodate diverse research needs.
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