Rabbit Polyclonal UBE2V1 Antibody

The UBE2V1 antibody is a research tool designed to detect and study the ubiquitin-conjugating enzyme E2 V1 (UBE2V1), a key component of the ubiquitin-proteasome system involved in protein post-translational modification. UBE2V1. also known as UBE2V or CROC-1. lacks intrinsic catalytic activity but forms heterodimers with UBE2N (UBE2V1-UBE2N complex) to mediate Lys63-linked polyubiquitination, a non-degradative ubiquitination critical for DNA repair, NF-κB signaling, and immune response regulation. This antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate UBE2V1 expression, localization, and interactions in cellular contexts. Dysregulation of UBE2V1 has been implicated in cancer progression, inflammatory diseases, and neurodegenerative disorders, making its detection relevant for both basic research and clinical applications. Commercially available UBE2V1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes with validation across species (human, mouse, rat). Researchers rely on these reagents to explore UBE2V1's role in cellular stress responses, genomic stability, and therapeutic targeting pathways. Proper validation via knockout controls and functional assays remains essential to ensure antibody specificity in experimental models.