| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UBC16; UBC-16 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2W抗体的3篇参考文献示例(注：文献为虚拟示例，实际文献需通过数据库检索确认)：
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1. **文献名称**: "UBE2W regulates α-synuclein ubiquitination and degradation via N-terminal acetylation"
**作者**: Singh R.K. et al.
**摘要**: 本研究利用UBE2W特异性抗体进行免疫共沉淀和免疫印迹分析，揭示了UBE2W通过N端乙酰化修饰调控α-突触核蛋白的泛素化及蛋白酶体降解途径，为神经退行性疾病机制提供了新见解。
2. **文献名称**: "Development of a monoclonal antibody for UBE2W with high specificity in human tissues"
**作者**: Zhang Y. et al.
**摘要**: 报道了一种新型抗UBE2W单克隆抗体的开发与验证，通过免疫组化(IHC)和流式细胞术证明其在多种组织中的特异性，为UBE2W的蛋白定位及功能研究提供了可靠工具。
3. **文献名称**: "UBE2W-mediated ubiquitination in DNA damage response: Insights from antibody-based functional assays"
**作者**: Lee S. et al.
**摘要**: 通过UBE2W抗体筛选发现其参与DNA损伤修复过程，研究显示UBE2W通过调控BRCA1复合物的泛素化修饰影响同源重组修复效率，揭示了其在基因组稳定性中的作用。
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**说明**：实际文献需通过PubMed、Google Scholar等平台检索关键词“UBE2W antibody”“UBE2W function”获取。建议优先选择近5年发表的、涉及抗体验证或功能机制的研究。
The UBE2W antibody is a research tool designed to detect and study UBE2W (Ubiquitin-conjugating enzyme E2 W), a member of the E2 ubiquitin-conjugating enzyme family. UBE2W plays a critical role in the ubiquitin-proteasome system, mediating the transfer of ubiquitin to substrate proteins, often in collaboration with E3 ubiquitin ligases. Unlike many E2 enzymes, UBE2W uniquely catalyzes N-terminal ubiquitination, a non-canonical mechanism that tags substrate proteins for degradation or modulates their functional states. This enzyme is implicated in diverse cellular processes, including protein quality control, DNA repair, and regulation of signaling pathways.
UBE2W antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate UBE2W expression, localization, and interactions. Researchers employ these antibodies to explore UBE2W's involvement in diseases such as cancer and neurodegenerative disorders, where dysregulated ubiquitination is common. Additionally, UBE2W antibodies aid in studying its enzymatic activity, substrate specificity, and regulatory mechanisms, offering insights into potential therapeutic targets. Validated for specificity and sensitivity, these antibodies are essential for advancing understanding of ubiquitination dynamics and their pathological implications.
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