| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human UBE2Q2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2Q2抗体的3篇参考文献示例(注：以下文献信息为模拟示例，实际引用需核实真实来源)：
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1. **文献名称**: *UBE2Q2 Expression in Hepatocellular Carcinoma: Prognostic Implications*
**作者**: Zhang S, et al.
**摘要**: 该研究通过UBE2Q2抗体进行免疫组化分析，发现肝癌组织中UBE2Q2蛋白高表达与患者生存率降低显著相关，提示其可能作为肝癌预后的潜在生物标志物。
2. **文献名称**: *UBE2Q2 Promotes Colorectal Cancer Proliferation via Ubiquitination Pathways*
**作者**: Li M, et al.
**摘要**: 利用UBE2Q2抗体进行Western blot和功能实验，证实UBE2Q2通过泛素化降解抑癌蛋白，促进结直肠癌细胞增殖，可能成为治疗靶点。
3. **文献名称**: *UBE2Q2 as a Novel Biomarker in Triple-Negative Breast Cancer*
**作者**: Wang X, et al.
**摘要**: 通过UBE2Q2抗体检测三阴性乳腺癌组织，发现其表达水平与肿瘤侵袭性及转移风险正相关，为预后评估提供新方向。
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**提示**：实际研究中，建议通过PubMed、Web of Science等平台，以“UBE2Q2 antibody”、“UBE2Q2 biomarker”等关键词检索最新文献，并优先选择经过同行评审的高质量论文。
The UBE2Q2 antibody is a research tool designed to detect and study the ubiquitin-conjugating enzyme E2 Q2 (UBE2Q2), a member of the E2 ubiquitin-conjugating enzyme family. UBE2Q2 plays a role in the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and post-translational modification. Ubiquitination involves a cascade of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes, with E2s like UBE2Q2 transferring ubiquitin to substrate proteins, marking them for proteasomal degradation or functional modulation. While the precise biological functions of UBE2Q2 remain under investigation, it has been implicated in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Dysregulation of ubiquitination pathways is linked to diseases like cancer and neurodegenerative disorders, making UBE2Q2 a potential biomarker or therapeutic target.
The UBE2Q2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to analyze protein expression, localization, and interaction partners. Studies report variable UBE2Q2 expression across tissues and cancers, with some suggesting its upregulation in tumors like hepatocellular carcinoma, while others associate reduced levels with disease progression. These findings highlight context-dependent roles, necessitating further research. Commercial UBE2Q2 antibodies are typically validated for specificity and sensitivity, though performance may vary by application. Researchers utilize these tools to explore UBE2Q2's mechanistic contributions to UPS-related pathologies and its potential as a diagnostic or prognostic indicator.
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