| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RP58; MRD22; TAZ-1; ZNF238; C2H2-171 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ZBTB18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZBTB18抗体的示例参考文献(注：以下内容为示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: "ZBTB18 regulates neurogenic differentiation of neural stem cells through histone deacetylase recruitment"
**作者**: Smith J, et al.
**摘要**: 本研究利用ZBTB18抗体进行免疫沉淀和染色质免疫共沉淀(ChIP)，发现ZBTB18通过招募HDAC复合物抑制神经干细胞分化相关基因的表达，揭示了其在神经发育中的表观调控机制。
2. **文献名称**: "Aberrant ZBTB18 expression in glioblastoma correlates with tumor progression"
**作者**: Chen L, et al.
**摘要**: 通过ZBTB18抗体进行免疫组化和Western blot分析，发现胶质母细胞瘤中ZBTB18蛋白表达显著升高，且与患者预后不良相关，提示其作为潜在治疗靶点的可能性。
3. **文献名称**: "ZBTB18 antibody validation for chromatin binding studies in cortical neurons"
**作者**: García-Ruiz A, et al.
**摘要**: 该研究系统验证了ZBTB18抗体在神经元中的特异性，结合ChIP-seq技术鉴定出ZBTB18在基因组中结合的新靶点，为研究其转录调控功能提供了可靠工具。
4. **文献名称**: "Loss of ZBTB18 impairs synaptic plasticity in a mouse model of intellectual disability"
**作者**: Wang Y, et al.
**摘要**: 通过ZBTB18抗体检测小鼠脑组织中的蛋白表达，发现ZBTB18缺失导致突触可塑性相关蛋白表达异常，阐明了其在智力障碍中的分子机制。
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建议通过PubMed、Google Scholar等平台，以“ZBTB18 antibody”及研究领域(如神经科学、癌症)为关键词检索最新文献。
The ZBTB18 antibody is a crucial tool for studying the ZBTB18 protein, a transcription factor belonging to the zinc finger and BTB domain-containing (ZBTB) family. Also known as ZNF238 or RP58. ZBTB18 plays a pivotal role in neurodevelopment, including neuronal differentiation, cortical layer formation, and synaptic plasticity. Structurally, it contains an N-terminal BTB domain for protein interactions and C-terminal C2H2 zinc finger motifs for DNA binding, enabling its function as a transcriptional repressor. ZBTB18 regulates gene expression by recruiting chromatin-modifying complexes, such as histone deacetylases (HDACs), to suppress target genes involved in cell cycle progression and differentiation.
Antibodies targeting ZBTB18 are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and DNA-binding activity. These antibodies are typically raised in rabbits or mice and validated for specificity across human, mouse, and rat models. Research highlights ZBTB18's involvement in neurological disorders (e.g., intellectual disability, autism spectrum disorders) and cancers (e.g., glioblastoma, neuroblastoma), where its dysregulation correlates with tumor progression or impaired neurogenesis. Studies also explore its role in epigenetic regulation and interactions with pathways like Notch and Wnt. As such, ZBTB18 antibodies are vital for unraveling its contributions to development, disease mechanisms, and potential therapeutic targets.
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