关键信息
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基因名
LACTB2
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简介
As an endoribonuclease, LACTB2 protein preferentially cleaves the 3' purine-pyrimidine dinucleotide motif within single-stranded RNA, producing a cleavage product with a free 3'-OH group. It is worth noting that its enzymatic activity is only directed against single-stranded RNA and does not extend to double-stranded RNA or DNA. LACTB2 Protein, Human (GST) is the recombinant human-derived LACTB2 protein, expressed by E. coli , with N-GST labeled tag.
- 应用
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别名
Beta-Lactamase-Like Protein 2; LACTB2
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种属
Human
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表达系统
E. coli
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q53H82
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表达区间
M1-L288
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氨基酸序列
MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL
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蛋白长度
Full Length
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分子量
56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LACTB2, a member of the lactoylglutathione lyase family, has recently garnered attention for its potential roles in cellular functions and disease mechanisms. This protein is implicated in critical biological processes, including oxidative stress response and metabolic regulation. Initial studies have suggested that LACTB2 may act as a regulator of apoptosis and inflammation, highlighting its relevance in cancer and neurodegenerative disorders. Despite its importance, the functional characterization of LACTB2 remains limited, with many of its biochemical pathways and interactors still unidentified. Recent advancements in proteomics and structural biology have opened new avenues for understanding LACTB2’s role at the molecular level. Recombinant expression of LACTB2 offers a promising approach to investigate its enzymatic activity, substrate specificity, and role in cellular signaling pathways. By producing LACTB2 in a controlled laboratory setting, researchers aim to elucidate its functional properties, paving the way for potential therapeutic strategies targeting LACTB2-related pathways. Furthermore, understanding the regulatory mechanisms involving LACTB2 may provide insights into its contribution to various pathophysiological conditions, ultimately leading to the identification of novel biomarkers or drug targets. Thus, the study of LACTB2 as a recombinant protein holds significant promise for advancing our knowledge of its biological functions and therapeutic potential, making it a focal point of research in the fields of biochemistry and molecular biology.
