| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SPI-C |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SPIC抗体的3篇参考文献示例(内容基于假设性研究，建议通过学术数据库核实)：
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1. **文献名称**: *SPIC Antibodies as Novel Biomarkers in Systemic Lupus Erythematosus*
**作者**: Zhang L, et al.
**摘要**: 该研究首次报道了抗SPIC抗体在系统性红斑狼疮(SLE)患者血清中的存在，发现其与疾病活动度(如肾脏损伤)显著相关，提示其可能作为SLE的新型诊断标志物。
2. **文献名称**: *Transcriptional Regulation of SPIC in Macrophage Polarization: Implications for Autoimmunity*
**作者**: Kimura T, et al.
**摘要**: 文章通过SPIC特异性抗体分析，揭示了SPIC蛋白在巨噬细胞M2极化中的关键作用，并发现其表达异常可能促进自身免疫性疾病(如类风湿关节炎)的发展。
3. **文献名称**: *Anti-SPIC Antibodies in Primary Sjögren’s Syndrome: Clinical and Molecular Correlations*
**作者**: García-Carmona Y, et al.
**摘要**: 研究发现约15%的原发性干燥综合征患者血清中存在抗SPIC抗体，且与唾液腺炎症程度及特定基因变异(如IRF5)相关，为疾病分型提供了新依据。
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**注意**：以上文献为示例，实际引用时需通过PubMed、Google Scholar等平台核实具体信息。SPIC抗体的研究可能涉及不同领域(如转录因子功能或自身抗体临床应用)，建议根据研究背景筛选文献。
SPIC (Spi-C) antibody is a tool used to detect the SPIC protein, a transcription factor belonging to the ETS family, which shares structural homology with PU.1 and Spi-B. SPIC is encoded by the *SPIC* gene and plays a critical role in regulating gene expression in specific immune cell lineages. It is notably expressed in red pulp macrophages (RPMs) in the spleen, where it governs their differentiation and functional specialization, including iron recycling and erythrocyte clearance. SPIC is also implicated in B-cell development and the regulation of inflammatory responses, particularly in macrophages involved in tissue homeostasis and immune tolerance.
SPIC antibodies are widely utilized in research to study protein expression patterns, cellular localization, and functional roles in both physiological and pathological contexts. They are employed in techniques like immunohistochemistry, Western blotting, and flow cytometry. Studies using these antibodies have linked SPIC dysregulation to diseases such as atherosclerosis, autoimmune disorders, and certain cancers, where abnormal macrophage activity or B-cell dysfunction occurs.
Clinically, SPIC is explored as a potential biomarker for macrophage-related pathologies or hematological malignancies. However, challenges remain in standardizing antibody specificity across experimental models. Ongoing research aims to elucidate SPIC's interaction networks and therapeutic potential in modulating immune responses.
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