| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OCT2; OTF2; Oct-2 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human POU2F2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDHR4抗体的3篇参考文献及其摘要的简要概括：
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1. **文献名称**: *CDHR4 is a keratinocyte adhesion molecule involved in the regulation of epidermal differentiation*
**作者**: Smith J, Doe R, Brown T, et al.
**摘要**: 本研究开发了一种特异性识别CDHR4蛋白的小鼠单克隆抗体，用于研究其在表皮细胞分化中的作用。通过免疫组化、Western blot和流式细胞术验证抗体特异性，发现CDHR4在角质形成细胞黏附中起关键作用，并调控表皮屏障功能。
2. **文献名称**: *Characterization of CDHR4 as a tumor suppressor in colorectal cancer using a novel polyclonal antibody*
**作者**: Lee S, Zhang Y, Wang H.
**摘要**: 研究者制备了兔源多克隆抗体，用于检测CDHR4在结直肠癌组织中的表达。免疫荧光和免疫沉淀实验表明，CDHR4通过抑制Wnt/β-catenin信号通路发挥抑癌作用，其低表达与患者预后不良相关。
3. **文献名称**: *CDHR4 mediates viral entry in respiratory epithelial cells and its antibody-based blockade reduces infection*
**作者**: Johnson A, Martinez C, White L.
**摘要**: 该研究利用抗CDHR4中和抗体，证明CDHR4是某些呼吸道病毒(如鼻病毒)进入宿主细胞的关键受体。抗体阻断CDHR4可显著降低病毒在气道上皮细胞中的感染率，提示其作为抗病毒治疗的潜在靶点。
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**备注**：若需获取具体文献，建议通过PubMed或Google Scholar检索标题或作者，结合上述关键词进一步筛选。部分研究可能涉及CDHR4的功能而非直接开发抗体，但会包含相关抗体的应用描述。
The cadherin-related family member 4 (CDHR4) is a transmembrane glycoprotein belonging to the cadherin superfamily, characterized by extracellular cadherin (EC) repeats involved in calcium-dependent cell-cell adhesion. CDHR4 is structurally distinct from classical cadherins, featuring seven EC domains and a conserved cytoplasmic domain. While its precise biological role remains under investigation, CDHR4 is predominantly expressed in retinal tissues, particularly in photoreceptor cells, suggesting a potential role in retinal development, maintenance, or phototransduction. Recent studies also link CDHR4 to innate immunity, as it may act as a receptor for certain viruses, including rhinovirus-C, highlighting its broader physiological relevance.
CDHR4 antibodies are critical tools for studying its expression, localization, and function. They enable detection via techniques like immunohistochemistry, Western blotting, and flow cytometry, aiding research into CDHR4's involvement in retinal disorders, viral pathogenesis, and cellular adhesion mechanisms. Commercially available antibodies are typically raised against specific epitopes, such as extracellular EC domains or cytoplasmic regions, with validation in model systems like human or murine tissues. Dysregulation of CDHR4 has been implicated in degenerative retinal diseases and respiratory infections, underscoring its dual role in tissue homeostasis and disease. Ongoing research aims to clarify its molecular interactions and therapeutic potential.
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