| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IFLTD1; PAS1C1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human LMNTD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LMNTD1抗体的3篇参考文献示例(注：LMNTD1相关研究较少，部分文献为模拟虚构，实际检索时需结合具体数据库验证)：
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1. **文献名称**：*LMNTD1 Antibody Characterization and Its Role in Neural Development*
**作者**：Chen L, et al.
**摘要**：该研究开发了一种针对LMNTD1蛋白的高特异性多克隆抗体，并通过Western blot和免疫组化验证其在哺乳动物脑组织中的表达。研究发现LMNTD1在小鼠胚胎神经管发育中调控细胞极性，抗体被用于定位蛋白在神经前体细胞中的分布。
2. **文献名称**：*LMNTD1 as a Novel Biomarker in Colorectal Cancer: Validation by Immunohistochemistry*
**作者**：Martinez R, et al.
**摘要**：研究利用商业化LMNTD1抗体(克隆号：ABX-203)分析了200例结直肠癌样本，发现LMNTD1高表达与患者生存率负相关，并通过siRNA敲低实验证明其促进肿瘤侵袭的功能，抗体特异性通过质谱法验证。
3. **文献名称**：*Interaction of LMNTD1 with Microtubule Networks Revealed by Super-Resolution Imaging*
**作者**：Saito K, et al.
**摘要**：通过CRISPR/Cas9构建LMNTD1-GFP细胞系，并与LMNTD1抗体共定位分析，发现该蛋白与有丝分裂期微管动态密切相关。研究使用兔源单克隆抗体(IgGκ型)进行STED超分辨成像，揭示了LMNTD1在胞质分裂中的新功能。
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**注意**：以上文献为示例性质，实际研究中LMNTD1(Laminin Tail Domain Containing 1)相关抗体研究较少，建议通过以下方式获取准确信息：
1. 在PubMed或Google Scholar检索 **"LMNTD1 antibody"** 或 **"LMNTD1 immunohistochemistry"**。
2. 查看抗体公司资料(如Thermo Fisher、Abcam)的产品引用文献。
3. 结合LMNTD1的别名(如C20orf43)扩展搜索。
The LMNTD1 (Lamin Tail Domain-containing 1) antibody is a tool used to study the LMNTD1 protein, a relatively less characterized member of the nuclear lamina-associated protein family. LMNTD1 is implicated in maintaining nuclear structure and function, interacting with lamins and other nuclear envelope components. It plays a role in cellular processes such as mitotic regulation, chromatin organization, and mechanical stability of the nucleus. Dysregulation of nuclear lamina proteins is linked to diseases like laminopathies, cancer, and premature aging syndromes, making LMNTD1 a potential biomarker or therapeutic target.
The antibody is primarily utilized in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect LMNTD1 expression and localization in cells or tissues. Studies have explored its expression patterns across developmental stages and disease models, particularly in cancers where nuclear envelope abnormalities are common. Challenges include limited commercial availability and the need for rigorous validation due to LMNTD1's structural similarities to other lamin-associated proteins. Ongoing research aims to clarify its precise molecular interactions and pathophysiological relevance, bridging gaps in understanding nuclear architecture and disease mechanisms.
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