| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | NIPK; SINK; TRB3; SKIP3; C20orf97 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于 **TRIB3抗体** 的参考文献及其简要摘要：
1. **文献名称**: *TRIB3 regulates tumorigenesis through modulating Wnt/β-catenin signaling*
**作者**: Du J, et al. (2013)
**摘要**: 研究利用TRIB3特异性抗体检测其在多种肿瘤细胞中的表达，发现TRIB3通过抑制β-catenin降解促进肿瘤发生，提示其作为癌症治疗靶点的潜力。
2. **文献名称**: *Tribbles homolog 3 (TRIB3) mediates ER stress-induced insulin resistance in adipocytes*
**作者**: Qi L, et al. (2010)
**摘要**: 通过TRIB3抗体进行免疫印迹和免疫沉淀实验，发现TRIB3在内质网应激条件下上调，抑制Akt磷酸化，导致脂肪细胞胰岛素抵抗，与代谢综合征相关。
3. **文献名称**: *TRIB3 suppresses AKT activation and promotes apoptosis in response to cellular stress*
**作者**: Ohoka N, et al. (2005)
**摘要**: 使用TRIB3抗体验证其在内质网应激中的表达，发现TRIB3作为ATF4下游靶点，通过与AKT结合抑制其活性，诱导细胞凋亡，参与应激反应调控。
4. **文献名称**: *TRIB3 modulates autophagy in neurodegenerative diseases via mTOR signaling*
**作者**: Lima TI, et al. (2018)
**摘要**: 研究通过TRIB3抗体检测阿尔茨海默病模型中的蛋白定位，表明TRIB3通过抑制mTOR通路增强自噬，可能缓解神经退行性病变。
这些文献均通过TRIB3抗体进行蛋白表达分析，揭示了其在癌症、代谢疾病和神经疾病中的关键作用机制。
**Background of TRIB3 Antibody**
TRIB3 (Tribbles homolog 3) is a pseudokinase belonging to the Tribbles family of proteins, which regulate cellular processes such as stress response, metabolism, apoptosis, and cancer progression. Unlike typical kinases, TRIB3 lacks catalytic activity but acts as a scaffold or modulator in signaling pathways. It interacts with key molecules like ATF4. CHOP, and AKT, influencing pathways such as the unfolded protein response (UPR), insulin signaling, and cell survival. TRIB3 is implicated in diseases including cancer, diabetes, and neurodegenerative disorders, where its expression often correlates with disease progression or therapeutic resistance.
TRIB3 antibodies are essential tools for detecting and quantifying TRIB3 protein levels in research. They enable the study of TRIB3's role in cellular stress, metabolic dysregulation, and tumorigenesis through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Due to TRIB3's context-dependent roles (e.g., acting as a tumor suppressor or promoter), reliable antibodies are critical for accurate experimental outcomes. Most TRIB3 antibodies are generated using immunogenic peptides or recombinant protein fragments, and their specificity is validated via knockout controls or siRNA-mediated silencing. Researchers utilize these antibodies to explore TRIB3's involvement in disease mechanisms, therapeutic targeting, and biomarker discovery, underscoring its growing relevance in translational medicine.
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