| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/45-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HRF; p02; p23; TCTP |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TPT1(TCTP)抗体的3篇参考文献的简要信息：
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1. **文献名称**: *TCTP as a therapeutic target in cancer*
**作者**: Amson, R., et al.
**摘要**: 该研究探讨了TCTP(TPT1)在肿瘤发生中的作用，并利用特异性抗体验证其在乳腺癌细胞中的高表达。研究提出TCTP抗体可用于靶向治疗，通过抑制TCTP功能诱导肿瘤细胞凋亡。
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2. **文献名称**: *Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase α subunit and inhibits the pump activity*
**作者**: Jung, J., et al.
**摘要**: 研究通过免疫共沉淀(使用TPT1抗体)揭示TCTP与Na,K-ATPase的相互作用，并证明其通过调控离子泵活性影响细胞应激反应，为癌症治疗的分子机制提供新见解。
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3. **文献名称**: *TCTP overexpression as a prognostic marker in hepatocellular carcinoma*
**作者**: Chan, T.H., et al.
**摘要**: 利用TPT1抗体对肝癌组织进行免疫组化分析，发现TCTP高表达与患者不良预后显著相关，提示其可作为肝癌诊断和预后的生物标志物。
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**备注**: TPT1(TCTP)抗体相关研究多集中在癌症机制、治疗靶点及诊断标记物领域。如需具体文献链接或扩展内容，可进一步提供研究方向或数据库筛选条件。
The TPT1 (Tumor Protein Translationally-Controlled 1) antibody is a tool used to study the TPT1 protein, a highly conserved, multifunctional molecule encoded by the *TPT1* gene. Originally identified as a translationally controlled tumor protein, TPT1 (also called TCTP) is ubiquitously expressed across eukaryotes and plays roles in cell cycle regulation, apoptosis, calcium homeostasis, and stress response. Structurally, it is a small cytoplasmic protein (~19-21 kDa) with a flexible conformation, enabling interactions with diverse binding partners like microtubules, Bcl-2 family proteins, and mTOR pathway components.
TPT1 is implicated in cancer progression, as its overexpression correlates with tumor growth, metastasis, and therapy resistance. It regulates pathways such as mTOR signaling (promoting cell proliferation) and p53 stabilization (modulating apoptosis). Additionally, TPT1 participates in immune responses and developmental processes. Antibodies targeting TPT1 are widely used in research to detect its expression levels via Western blot, immunohistochemistry, or immunofluorescence, aiding studies on cancer biology, neurodegeneration, and autophagy. Some commercial TPT1 antibodies are raised in rabbits or mice using recombinant protein antigens or synthetic peptides. Validation includes specificity checks using knockout cell lines or siRNA-mediated knockdown. Beyond research, TPT1 antibodies have potential diagnostic applications, as elevated TPT1 levels in serum or tissues may serve as biomarkers for certain cancers or inflammatory diseases.
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