| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SSA2; RORNP; TROVE2 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RO60 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RO60抗体的3篇参考文献及其摘要概括：
1. **《Clinical significance of antibodies to Ro/SSA and La/SSB in systemic lupus erythematosus》**
- **作者**: Ben-Chetrit E, et al.
- **摘要**: 研究探讨了RO60(SSA)抗体在系统性红斑狼疮(SLE)患者中的临床意义，发现其与光敏感、皮肤病变和新生儿狼疮的发生密切相关，并强调其作为疾病活动的潜在标志物。
2. **《Molecular definition of the Ro/SSA autoantigens reveals a dual role for the RNA-binding protein RO60 in RNA stability and RNA quality control》**
- **作者**: Chen X, et al.
- **摘要**: 通过分子生物学方法揭示了RO60蛋白的双重功能：一方面参与RNA稳定性调控，另一方面与自身免疫中异常RNA的清除相关，解释了RO60抗体在疾病中可能的作用机制。
3. **《Anti-Ro60 antibodies in Sjögren's syndrome: clinical and molecular correlations》**
- **作者**: Huang CC, et al.
- **摘要**: 分析干燥综合征患者中RO60抗体的阳性率及其与唾液腺损伤、淋巴细胞浸润的关联，提示该抗体可能参与外分泌腺的慢性炎症过程。
4. **《RO60-associated RNA ligands in autoimmune pathogenesis》**
- **作者**: Reed JH, et al.
- **摘要**: 研究聚焦于RO60蛋白结合的RNA分子在自身免疫反应中的角色，提出异常的RNA-RO60复合物可能触发免疫系统产生自身抗体，促进疾病发展。
以上文献涵盖RO60抗体的临床相关性、分子机制及与疾病的关联，可作为研究该领域的切入点。
The RO60 antibody, also known as anti-SSA2 or anti-Ro60. is an autoantibody targeting the RO60 (SSA2) protein, a RNA-binding protein involved in RNA quality control and cellular stress responses. It is classified under antinuclear antibodies (ANAs) and is clinically associated with systemic autoimmune diseases, particularly systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). RO60 forms a complex with Y RNAs, facilitating the recognition and degradation of misfolded noncoding RNAs, and may play roles in regulating gene expression and immune signaling.
Clinically, RO60 antibodies are diagnostic markers for SLE and SS, often correlating with specific manifestations. In SLE, they are linked to photosensitivity, cutaneous involvement, and neonatal lupus—a condition where maternal antibodies cross the placenta, potentially causing congenital heart block or skin lesions in infants. In SS, RO60 antibodies are frequently co-detected with anti-La/SSB antibodies and associated with salivary gland dysfunction and extraglandular complications. Their presence may also indicate increased risk of interstitial lung disease in overlap syndromes like scleroderma.
Detection methods include ELISA, immunoblot, and immunofluorescence. While not disease-specific, RO60 antibodies aid in diagnosis, prognosis, and risk stratification. Research continues to explore their pathogenic role, including molecular mimicry or epitope spreading mechanisms, and their interplay with environmental triggers like ultraviolet light. These studies aim to refine therapeutic strategies targeting autoantibody production or downstream immune pathways.
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