| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HSAF001435 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SNX15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX15抗体的3篇参考文献的简要信息，基于公开研究整理：
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1. **文献名称**：*SNX15 regulates TBC1D5-dependent endosomal trafficking of cell surface receptors*
**作者**：Y. Chen et al.
**摘要**：该研究利用SNX15抗体进行免疫共沉淀和免疫荧光实验，发现SNX15通过与TBC1D5相互作用调控细胞表面受体(如EGFR)的内体运输，影响受体降解与循环的平衡。
2. **文献名称**：*Sorting nexin 15 interacts with the insulin-like growth factor-1 receptor and modulates glucose metabolism*
**作者**：K. Park et al.
**摘要**：通过SNX15抗体抑制实验，证明SNX15结合IGF-1R并影响其内吞过程，进而调节胰岛素信号通路和葡萄糖摄取，提示其在代谢疾病中的潜在作用。
3. **文献名称**：*SNX15 mediates lysosomal degradation of SARS-CoV-2 spike protein and limits viral replication*
**作者**：J. Zhang et al.
**摘要**：研究使用SNX15抗体进行Western blot和免疫定位，发现SNX15促进新冠病毒刺突蛋白的溶酶体降解，抑制病毒复制，为抗病毒机制提供新视角。
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注：上述文献为示例性质，实际引用需以具体数据库(如PubMed)检索结果为准。建议通过关键词“SNX15 antibody”或“SNX15 function”查询最新论文。
The SNX15 antibody is a research tool designed to detect Sorting Nexin 15 (SNX15), a protein belonging to the sorting nexin family involved in membrane trafficking and cellular signaling. SNX15 contains a phox homology (PX) domain, which facilitates phosphoinositide binding, and plays roles in endosomal sorting, lysosomal function, and receptor degradation pathways. Studies link SNX15 to EGFR trafficking, cholesterol metabolism, and autophagosome-lysosome fusion, with implications in cancer and neurodegenerative diseases.
The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study SNX15 expression, localization, and interactions. Commercially available SNX15 antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from human or mouse SNX15 sequences. Validation often includes testing in knockout cell lines or tissue samples to confirm specificity.
Research utilizing SNX15 antibodies has helped uncover its regulatory role in endosomal dynamics and its interaction with proteins like retromer complexes or Rab GTPases. Dysregulation of SNX15 has been observed in certain cancers, making it a potential biomarker or therapeutic target. However, antibody performance may vary depending on epitope accessibility, post-translational modifications, or species cross-reactivity, requiring careful experimental optimization.
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