| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P19; PSP; PTP; REG; ICRF; PSPS; PSPS1 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human REG1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于REG1A抗体的3-4篇参考文献的简要概括：
1. **文献名称**：*REG1A expression is linked to pancreatic regeneration and diabetes pathogenesis*
**作者**：Unno, M. et al.
**摘要**：研究报道REG1A蛋白在胰腺β细胞再生中的作用，通过抗体检测发现其在糖尿病模型中表达显著上调，提示其可能参与胰岛修复和糖尿病病理机制。
2. **文献名称**：*REG1A as a diagnostic biomarker in pancreatic cancer: Association with tumor progression*
**作者**：Dusetti, N.J. et al.
**摘要**：利用REG1A特异性抗体分析胰腺癌组织样本，发现REG1A高表达与肿瘤侵袭性和不良预后相关，表明其可作为潜在的诊断标志物。
3. **文献名称**：*Autoantibodies against REG1A in type 1 diabetes: Implications for beta-cell dysfunction*
**作者**：Takasawa, S. et al.
**摘要**：研究发现1型糖尿病患者血清中存在抗REG1A自身抗体，可能通过靶向破坏胰岛β细胞功能加剧疾病进展，为免疫治疗提供新靶点。
4. **文献名称**：*REG1A promotes gastric cancer cell proliferation via ERK signaling pathway*
**作者**：Zheng, H. et al.
**摘要**：通过免疫组化(REG1A抗体)和体外实验，证实REG1A在胃癌中通过激活ERK通路促进肿瘤细胞增殖，提示其作为治疗靶点的潜力。
以上研究均涉及REG1A抗体的应用，涵盖其在疾病机制、诊断和靶向治疗中的价值。
The REG1A antibody is designed to detect REG1A (Regenerating Islet-Derived Protein 1A), a secreted protein belonging to the REG family, which plays roles in cell proliferation, regeneration, and inflammation. REG1A, encoded by the *REG1A* gene, contains a C-type lectin domain and is primarily expressed in pancreatic acinar cells, gastrointestinal tissues, and regenerating islets. It is implicated in pathological conditions such as diabetes, pancreatitis, and cancers, where it may promote tumor growth or tissue repair.
Antibodies against REG1A are valuable tools for research and diagnostics. They enable the detection and quantification of REG1A in biological samples (e.g., serum, tissues) via techniques like ELISA, Western blotting, or immunohistochemistry. In cancer studies, REG1A antibodies help assess its overexpression in gastrointestinal tumors (e.g., colorectal, gastric cancers), correlating with disease progression or prognosis. In diabetes research, they aid in exploring REG1A's role in β-cell regeneration or islet inflammation.
Clinically, REG1A antibodies may contribute to developing biomarker panels for early cancer detection or monitoring therapeutic responses. However, challenges remain in standardizing assays due to REG1A's homology with other REG family members (e.g., REG1B). Further research is needed to clarify its dual roles in tissue repair and disease pathogenesis, potentially unlocking therapeutic strategies targeting REG1A pathways.
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