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Rabbit Polyclonal MSMB Antibody

  • 中文名: MSMB抗体
  • 别    名: MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
货号: IPDX08613
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/500-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于MSMB抗体的参考文献,简要列举如下:

1. **文献名称**:*Development of a novel monoclonal antibody against MSMB for prostate cancer diagnosis*

**作者**:Smith J, et al.

**摘要**:研究团队开发了一种高特异性抗MSMB单克隆抗体,验证其在前列腺癌组织中的表达水平,证实其作为诊断标志物的潜力,并通过免疫组化分析显示其在区分恶性与良性病变中的高敏感性。

2. **文献名称**:*MSMB as a biomarker in serum: Validation of an ELISA assay using a polyclonal antibody*

**作者**:Lee H, et al.

**摘要**:该研究利用多克隆MSMB抗体建立了一种新型ELISA检测方法,用于定量血清中MSMB水平,发现前列腺癌患者血清MSMB显著降低,提示其作为无创筛查工具的临床应用价值。

3. **文献名称**:*Targeting MSMB with antibody-drug conjugates in aggressive prostate cancer models*

**作者**:Garcia R, et al.

**摘要**:研究构建了靶向MSMB的抗体-药物偶联物(ADC),在体外和小鼠模型中显示其能选择性杀伤MSMB高表达的前列腺癌细胞,为治疗耐药性肿瘤提供了新策略。

注:以上文献信息为示例性内容,实际引用需根据具体论文调整。建议通过PubMed或Web of Science以“MSMB antibody”为关键词检索最新研究。

背景信息

Microseminoprotein-beta (MSMB), also known as β-microseminoprotein, is a small secretory protein primarily expressed in the prostate gland. It was first identified in seminal plasma and is involved in regulating semen liquefaction and immune modulation. MSMB has garnered significant attention due to its potential role as a biomarker, particularly in prostate cancer. Research indicates that MSMB expression is frequently downregulated in prostate tumors, correlating with disease progression and poor prognosis. This suppression is linked to hypermethylation of the MSMB promoter or genetic variations, such as the rs10993994 SNP.

MSMB antibodies are critical tools for detecting and quantifying MSMB protein levels in research and diagnostics. Polyclonal and monoclonal antibodies targeting specific epitopes of MSMB enable applications like immunohistochemistry, ELISA, and Western blotting. These antibodies help elucidate MSMB's biological functions, including its interaction with cysteine-rich secretory protein 3 (CRISP-3) and possible roles in apoptosis and tumor suppression.

Clinically, MSMB antibodies are explored for early cancer detection, monitoring therapeutic responses, and developing targeted therapies. Challenges include ensuring antibody specificity due to MSMB's structural homology with other semenogelin proteins. Ongoing studies aim to optimize MSMB-based assays and validate their utility in precision oncology, highlighting its dual significance in basic research and translational medicine.

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