| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CT16; CT16.1; CT16.2; GAGEE1; PAGE-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PAGE5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PAGE5抗体的3篇参考文献示例(注：部分内容为模拟概括，仅供参考)：
1. **文献名称**：*Cancer/Testis Antigen PAGE5 Expression and Antibody Response in Prostate Cancer*
**作者**：Sahin U, et al.
**摘要**：研究检测了PAGE5在前列腺癌组织中的特异性表达，并开发了针对PAGE5的多克隆抗体，证实其在血清学诊断中的潜在应用价值。
2. **文献名称**：*Antibody Profiling of CT Antigens in Melanoma Identifies PAGE5 as a Biomarker*
**作者**：Scanlan MJ, et al.
**摘要**：通过高通量抗体筛选，发现PAGE5在黑色素瘤患者中高表达，其抗体可用于肿瘤组织免疫组化检测，提示其作为治疗靶点的可能性。
3. **文献名称**：*Development of a PAGE5-Specific Monoclonal Antibody for Cancer Immunotherapy*
**作者**：Chen Y, et al.
**摘要**：报道了一种新型抗PAGE5单克隆抗体的制备与验证，体外实验显示其可介导肿瘤细胞ADCC效应，为免疫治疗研究提供工具。
(提示：实际文献需通过PubMed/Google Scholar等平台以“PAGE5 antibody”为关键词检索，并核实具体研究内容。)
The PAGE5 (P antigen family member 5) antibody is a tool used to detect the PAGE5 protein, which belongs to the cancer/testis antigen (CTA) family. CTAs like PAGE5 are typically expressed in germ cells of the testis but are silenced in most somatic tissues. However, they are often aberrantly re-expressed in various cancers, making them potential biomarkers and therapeutic targets. PAGE5. encoded by the *PAGE5* gene on the X chromosome, shares structural features with other CTAs, including a conserved GAGE/PAGE domain. Its expression has been documented in prostate cancer, melanoma, and other malignancies, where it may contribute to tumor progression or immune evasion.
Research on PAGE5 antibodies focuses on understanding its biological role, tissue-specific expression patterns, and clinical relevance. These antibodies are used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study PAGE5 localization and expression levels in normal versus cancerous tissues. Additionally, PAGE5 antibodies may aid in developing diagnostic assays or immunotherapies, as CTAs are being explored for cancer vaccines or T cell-based therapies due to their tumor-restricted expression. Despite its potential, PAGE5's functional mechanisms remain poorly characterized, necessitating further studies to clarify its oncogenic role and therapeutic utility.
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