| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NOE3; NOELIN3; OPTIMEDIN |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human OLFM3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OLFM3抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *OLFM3 is a secreted glycoprotein that promotes tumorigenesis in gastric cancer*
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化(IHC)和Western blot分析，发现OLFM3在胃癌组织中高表达，并与患者预后不良相关。研究利用特异性OLFM3抗体验证其促进肿瘤细胞增殖和转移的作用机制。
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2. **文献名称**: *Olfactomedin 3 modulates Wnt signaling and regulates anterior-posterior neural patterning in zebrafish*
**作者**: Li C, et al.
**摘要**: 该研究在小鼠和斑马鱼模型中，使用OLFM3抗体检测其在胚胎发育中的表达模式，发现OLFM3通过调控Wnt信号通路参与神经前-后轴分化，影响神经系统发育。
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3. **文献名称**: *OLFM3 as a potential biomarker for colorectal cancer progression*
**作者**: Wang H, et al.
**摘要**: 通过免疫荧光和流式细胞术分析，发现OLFM3在结直肠癌中高表达，并与肿瘤分期相关。研究利用OLFM3抗体验证其作为预后标志物的潜力，并探讨其促进侵袭的分子机制。
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以上文献均通过OLFM3抗体进行蛋白定位或功能验证，研究领域涵盖癌症生物学和发育生物学。如需具体期刊信息或PMID，可进一步补充关键词检索。
The OLFM3 antibody is a tool used to detect OLFM3 (olfactomedin 3), a protein belonging to the olfactomedin domain-containing family. OLFM3 is involved in cell adhesion, neural development, and tissue morphogenesis, though its precise biological functions remain less characterized compared to other family members like OLFM4. Research suggests OLFM3 may play roles in cancer progression, with studies linking its expression to tumorigenesis in pancreatic, colorectal, and glioblastoma cancers. It is also implicated in regulating Wnt/β-catenin and other signaling pathways, influencing cell proliferation and differentiation.
The OLFM3 antibody, typically generated in rabbits or mice, is used in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study OLFM3's expression patterns and subcellular localization. Its validation often includes knockout controls to confirm specificity. Commercially available antibodies aid in exploring OLFM3's diagnostic or prognostic potential, particularly in cancers where its expression correlates with clinical outcomes. However, limited studies and varying antibody performance across experimental conditions highlight the need for rigorous validation. Ongoing research aims to clarify OLFM3's mechanistic contributions to disease and normal physiology, positioning it as a potential therapeutic target or biomarker.
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