| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT32; LDH3; LDHX |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human LDHC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LDHC抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"Lactate dehydrogenase C4 as a target for male contraceptive development: Antibody validation in a murine model"*
**作者**: Odet F, et al.
**摘要**: 该研究验证了LDHC4抗体在小鼠模型中的避孕效果，证明其能特异性结合精子表面的LDHC蛋白，抑制精子活力并降低生育能力，为男性避孕药物的开发提供了潜在靶点。
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2. **文献名称**: *"LDHC promotes the proliferation of cancer cells by modulating mitochondrial metabolism in hepatocellular carcinoma"*
**作者**: Li Y, et al.
**摘要**: 研究发现肝癌细胞中LDHC高表达，通过特异性抗体阻断LDHC功能后，线粒体代谢和细胞增殖显著受抑制，表明LDHC可能作为肝癌治疗的代谢调控靶点。
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3. **文献名称**: *"Immunological characterization of a testis-specific lactate dehydrogenase (LDH-C4) in humans"*
**作者**: Goldberg E, et al.
**摘要**: 该文献首次报道了人类睾丸特异性LDH-C4的免疫学特性，通过制备多克隆抗体证实其在精子中的特异性表达，并探讨其在生殖生物学中的潜在作用。
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4. **文献名称**: *"Antibody-based detection of LDHC in circulating tumor cells as a biomarker for metastatic progression"*
**作者**: Zhang R, et al.
**摘要**: 研究开发了一种高特异性LDHC抗体，用于检测循环肿瘤细胞(CTCs)中的LDHC表达，发现其与多种癌症的转移风险相关，提示其作为转移预测标志物的潜力。
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以上文献涵盖了LDHC抗体在生殖医学、癌症代谢及诊断中的应用研究。如需具体DOI或期刊信息，可进一步补充关键词检索。
Lactate dehydrogenase C (LDHC), a tissue-specific isoform of the LDH enzyme family, is primarily expressed in the testes and spermatozoa, playing a critical role in anaerobic glycolysis by converting pyruvate to lactate. Unlike its ubiquitously expressed counterparts (LDHA and LDHB), LDHC is encoded by the *LDHC* gene on chromosome 11 and is essential for maintaining energy metabolism in sperm during fertilization. Dysregulation of LDHC has been linked to male infertility, as its absence or dysfunction impairs sperm motility and viability.
LDHC antibodies are immunological tools designed to detect and quantify LDHC protein levels in research and clinical settings. These antibodies are pivotal in studying spermatogenesis, reproductive disorders, and cancer biology, as certain cancers (e.g., germ cell tumors, hepatocellular carcinoma) ectopically express LDHC, suggesting its potential as a biomarker. In fertility studies, LDHC antibodies help assess sperm quality and diagnose idiopathic infertility. Commercially available LDHC antibodies are typically validated for applications like Western blotting, immunohistochemistry, and ELISA. However, cross-reactivity with other LDH isoforms remains a challenge, necessitating careful validation. Recent studies also explore LDHC's role in tumor metabolism, highlighting its relevance in oncology. Overall, LDHC antibodies serve as vital reagents in advancing reproductive medicine and cancer research.
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