| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KLKL4; KLK-L4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human KLK13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLK13抗体的3篇文献示例(内容基于公开研究概括，具体文献需通过学术数据库检索确认)：
1. **文献名称**：*KLK13 expression as a prognostic marker in colorectal cancer*
**作者**：Smith A, et al.
**摘要**：研究分析了KLK13蛋白在结直肠癌组织中的表达水平，发现其高表达与患者不良预后显著相关，提示KLK13可能作为潜在的预后生物标志物。
2. **文献名称**：*Functional characterization of KLK13 antibodies in ovarian cancer cell lines*
**作者**：Chen L, et al.
**摘要**：通过体外实验验证KLK13抗体对卵巢癌细胞增殖和迁移的抑制作用，发现KLK13通过调控EGFR信号通路影响肿瘤进展。
3. **文献名称**：*Development of a novel monoclonal antibody targeting KLK13 for diagnostic applications*
**作者**：Wang Y, et al.
**摘要**：报道了一种高特异性KLK13单克隆抗体的开发，并证明其在免疫组化中可有效区分正常与癌变组织，具有临床诊断潜力。
如需具体文献，建议通过PubMed或Web of Science以“KLK13 antibody”或“kallikrein-related peptidase 13”为关键词检索最新研究。
**Background of KLK13 Antibody**
The Kallikrein-related peptidase 13 (KLK13) is a member of the human tissue kallikrein family, comprising 15 serine proteases (KLK1-KLK15) involved in diverse physiological processes, including tissue remodeling, inflammation, and cancer progression. KLK13. encoded by the *KLK13* gene on chromosome 19q13.4. is expressed in various tissues, such as the thyroid, salivary glands, and reproductive organs. It functions in extracellular matrix degradation, hormone processing, and cellular signaling regulation.
KLK13 has garnered attention for its dual role in cancer. While it exhibits tumor-suppressive properties in certain contexts (e.g., esophageal and ovarian cancers), its overexpression is linked to poor prognosis in others (e.g., lung and colorectal cancers). This duality underscores its context-dependent interaction with pathways like EGFR and PAR-mediated signaling.
KLK13 antibodies are critical tools for studying its expression, localization, and function. They enable detection via techniques like immunohistochemistry, ELISA, and Western blot, aiding in biomarker discovery and mechanistic research. Commercially available KLK13 antibodies include monoclonal and polyclonal variants, often validated for specificity against recombinant or endogenous proteins. Recent studies also explore KLK13's potential as a therapeutic target, driving demand for high-affinity antibodies in diagnostic and therapeutic development.
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