| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SAX2; LTXS1; SATX2; SPAX2; SPG58 |
| WB Predicted band size | 123 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KIF1C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIF1C抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*KIF1C regulates synaptic plasticity and cognition in mice through structural interaction with voltage-gated calcium channels*
**作者**：Li X, Zhang Y, Wang Y, et al.
**摘要**：该研究通过免疫共沉淀和免疫荧光技术，利用KIF1C抗体揭示了KIF1C蛋白与电压门控钙通道的相互作用，证明其对小鼠突触可塑性和认知功能的调控作用，为神经退行性疾病机制提供了新视角。
2. **文献名称**：*KIF1C modulates cancer cell migration and invasion by regulating focal adhesion dynamics*
**作者**：Dorahy DJ, Gu Q, Neufeld Z, et al.
**摘要**：研究采用KIF1C抗体进行Western blot和免疫组化分析，发现KIF1C通过调控黏着斑动力学影响癌细胞迁移和侵袭能力，其表达水平与乳腺癌转移潜力呈负相关。
3. **文献名称**：*Impaired mitochondrial transport in KIF1C-deficient neurons contributes to neurodegenerative pathology*
**作者**：van Bergeijk P, Adrian M, Hoogenraad CC, et al.
**摘要**：通过KIF1C抗体标记神经元中的线粒体运输，研究发现KIF1C缺失导致线粒体分布异常，引发轴突能量供应障碍，进而加剧神经退行性病变，提示KIF1C在神经元稳态中的关键作用。
(注：以上文献信息为虚拟示例，实际引用需根据具体文献调整。)
KIF1C (Kinesin Family Member 1C) is a microtubule-dependent motor protein belonging to the kinesin superfamily, which plays critical roles in intracellular transport, organelle positioning, and cellular dynamics. It is encoded by the *KIF1C* gene and is involved in regulating vesicle trafficking, Golgi apparatus organization, and endoplasmic reticulum (ER) dynamics. KIF1C contains a conserved N-terminal motor domain that hydrolyzes ATP to generate mechanical force, enabling movement along microtubules. Studies link KIF1C to cellular processes such as autophagy, cell migration, and immune response modulation. Dysregulation of KIF1C has been implicated in diseases, including cancer, neurodegenerative disorders, and autoimmune conditions like rheumatoid arthritis.
KIF1C antibodies are immunological tools used to detect and study the expression, localization, and function of KIF1C in research. They are essential for techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies aid in exploring KIF1C's role in pathological mechanisms, such as tumor metastasis or synaptic dysfunction. Commercial KIF1C antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes, and require validation for specificity via knockout controls or siRNA-based approaches. Their applications span basic cell biology, disease biomarker research, and therapeutic target validation.
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