| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1 |
| WB Predicted band size | 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KCNQ1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KCNQ1抗体的3篇参考文献概览(文献为示例性内容，具体引用需核实)：
1. **文献名称**：*KCNQ1 channel subunit assembly as assessed by FRET microscopy*
**作者**：Chen H et al.
**摘要**：研究利用KCNQ1特异性抗体结合荧光共振能量转移技术，揭示KCNQ1与辅助亚基KCNE1的相互作用机制，证明抗体在活细胞蛋白互作成像中的应用价值。
2. **文献名称**：*Autoantibodies against KCNQ1 in patients with immune-related cardiac dysfunction*
**作者**：Zhang L et al.
**摘要**：报道在自身免疫性心肌病患者血清中检测到抗KCNQ1抗体，并通过ELISA和免疫组化验证其与心脏钾通道功能异常的关联，提示抗体可能作为疾病生物标志物。
3. **文献名称**：*Loss of KCNQ1 expression in colorectal cancer revealed by immunohistochemistry*
**作者**：Wang Y et al.
**摘要**：采用KCNQ1抗体进行结直肠癌组织染色，发现肿瘤组织中KCNQ1蛋白表达显著下调，且低表达与患者预后不良相关，表明其在癌症中的潜在抑癌作用。
4. **文献名称**：*Epigenetic regulation of KCNQ1 in type 2 diabetes*
**作者**：Li X et al.
**摘要**：通过Western blot和染色质免疫沉淀(ChIP)结合KCNQ1抗体，发现2型糖尿病患者胰岛β细胞中KCNQ1表达受DNA甲基化调控，影响胰岛素分泌功能。
(注：以上文献信息为模拟生成，实际引用请通过PubMed或学术数据库检索确认。)
**Background of KCNQ1 Antibody**
KCNQ1. also known as Kv7.1. is a voltage-gated potassium channel encoded by the *KCNQ1* gene. It plays a critical role in maintaining electrochemical gradients across cell membranes, particularly in cardiac tissue, inner ear, and secretory epithelia. In the heart, KCNQ1 associates with the regulatory subunit KCNE1 to form the slow delayed rectifier potassium current (IKs), essential for repolarizing cardiac action potentials. Dysfunction of KCNQ1 due to mutations or aberrant expression is linked to cardiac arrhythmias (e.g., long QT syndrome type 1. atrial fibrillation) and hearing disorders (e.g., Jervell and Lange-Nielsen syndrome).
KCNQ1 antibodies are immunological tools designed to detect and quantify KCNQ1 protein expression in research and diagnostic settings. These antibodies are pivotal in studying channel localization, expression patterns, and molecular mechanisms underlying KCNQ1-related pathologies. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore tissue-specific distribution or altered expression in disease models. Additionally, KCNQ1 antibodies aid in elucidating interactions with regulatory partners (e.g., KCNE subunits) and assessing post-translational modifications that modulate channel activity.
The development and validation of specific, high-affinity KCNQ1 antibodies remain crucial for advancing research in cardiac electrophysiology, hearing biology, and targeted therapies for channelopathies.
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