Rabbit Polyclonal JMJD7 Antibody

The JMJD7 antibody is a tool used to study the JMJD7 (Jumonji domain-containing protein 7), a member of the Jumonji C (JmjC) domain-containing protein family. JMJD7 is implicated in epigenetic regulation, potentially influencing post-translational modifications of histones or other proteins. Although its precise biological function remains unclear, JMJD7 is suggested to play roles in developmental processes, cellular differentiation, and disease pathways, including cancer. Unlike many JmjC proteins, JMJD7 lacks classical demethylase activity due to incomplete catalytic motifs, but it may act as a regulatory cofactor or participate in protein-protein interactions. For example, studies link JMJD7 to the NF-κB and MAPK/ERK signaling pathways, suggesting involvement in inflammation or stress responses. The JMJD7 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interaction partners. Its specificity is validated using knockout controls or siRNA-mediated knockdowns. Research using this antibody has explored JMJD7's overexpression in certain cancers, such as gliomas, and its potential as a biomarker or therapeutic target. However, further functional studies are required to fully elucidate its mechanisms and clinical relevance.