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Rabbit Polyclonal JAKMIP2 Antibody

  • 中文名: JAKMIP2抗体
  • 别    名: NECC1; JAMIP2
货号: IPDX08450
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesNECC1; JAMIP2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human JAKMIP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于JAKMIP2抗体的假设性参考文献示例(请注意,实际文献需通过学术数据库验证):

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1. **"JAKMIP2 regulates dendritic spine development through JAK/STAT signaling"**

*Authors: Smith A, et al. (2020)*

**摘要**:本研究利用JAKMIP2特异性抗体进行免疫荧光染色,发现JAKMIP2在小鼠海马神经元中高表达,并调控树突棘形态发生。抗体验证显示其与JAK2存在共定位,提示二者在JAK/STAT通路中的协同作用。

2. **"Dysregulation of JAKMIP2 in autism spectrum disorder models"**

*Authors: Chen L, et al. (2019)*

**摘要**:通过Western blot和免疫组化(使用兔源JAKMIP2抗体),作者发现自闭症模型小鼠前额叶皮层中JAKMIP2蛋白水平显著降低,提示其可能参与突触可塑性异常及ASD病理机制。

3. **"JAKMIP2 interacts with microtubule networks in glioblastoma progression"**

*Authors: Kim H, et al. (2021)*

**摘要**:研究采用JAKMIP2抗体进行免疫共沉淀(Co-IP),证实其与微管蛋白β-III tubulin的相互作用,并揭示JAKMIP2通过稳定微管结构促进胶质母细胞瘤细胞侵袭。

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**注意**:以上为模拟示例,实际文献需查阅PubMed、Google Scholar等平台(搜索关键词如“JAKMIP2 antibody”、“JAKMIP2 function”)。若需具体文献,建议补充研究背景或联系领域专家获取。

背景信息

The JAKMIP2 (Janus Kinase and Microtubule-Interacting Protein 2) antibody is a tool used to study the JAKMIP2 protein, a member of the JAKMIP family implicated in neuronal development and synaptic function. JAKMIP2 contains conserved domains that facilitate interactions with Janus kinases (JAKs) and microtubule networks, linking it to JAK-STAT signaling pathways and cytoskeletal dynamics. It is predominantly expressed in the brain, where it regulates neuronal migration, axon guidance, and synaptic plasticity by modulating JAK-STAT activity and microtubule stability. Dysregulation of JAKMIP2 has been associated with neurodevelopmental disorders, including autism spectrum disorders and epilepsy. The antibody enables detection and localization of JAKMIP2 in tissues or cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. Researchers utilize it to explore JAKMIP2’s role in cellular signaling, its interaction partners, and its potential as a biomarker or therapeutic target in neurological diseases. Commercial JAKMIP2 antibodies are typically developed in hosts like rabbits or mice, validated for specificity against recombinant or endogenous protein epitopes. Ongoing studies focus on elucidating its molecular mechanisms in health and disease contexts.

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